Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

doi:10.1038/s41594-020-0440-6

	Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur
	Jin, Zhenming 1,2,3,4; Zhao, Yao1,2 ; Sun, Yuan 5; Zhang, Bing1,2 ; Wang, Haofeng1,2,6 ; Wu, Yan 5; Zhu, Yan1,2 ; Zhu, Chen1,2 ; Hu, Tianyu1,2 ; Du, Xiaoyu 1,2,3,4; Duan, Yinkai1,2 ; Yu, Jing1,2 ; Yang, Xiaobao1,2 ; Yang, Xiuna1,2 ; Yang, Kailin 7; Liu, Xiang 8; Guddat, Luke W.9; Xiao, Gengfu 5; Zhang, Leike 5; Yang, Haitao1,2 ; Rao, Zihe1,2,3,4,8
	2020-06
发表期刊	NATURE STRUCTURAL & MOLECULAR BIOLOGY (IF:12.5[JCR-2023],13.1[5-Year])
ISSN	1545-9993
EISSN	1545-9985
卷号	27 期号:6 页码:529-532
发表状态	已发表
DOI	10.1038/s41594-020-0440-6
摘要	A crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.
收录类别	SCI ; SCIE
资助项目	National Key R&D Program of China[2017YFC0840300][2020YFA0707500] ; Project of International Cooperation and Exchanges NSFC[81520108019] ; Science and Technology Commission of Shanghai Municipality[20431900200] ; Department of Science and Technology of Guangxi Zhuang Autonomous Region[2020AB40007] ; Natural Science Foundation of China[31970165]
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号	WOS:000531514100001
出版者	NATURE PUBLISHING GROUP
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/120878
专题	生命科学与技术学院_博士生免疫化学研究所_特聘教授组_抗体化学实验室免疫化学研究所_特聘教授组_饶子和组生命科学与技术学院_硕士生免疫化学研究所_PI研究组_杨海涛组
共同第一作者	Zhao, Yao; Sun, Yuan
通讯作者	Zhang, Leike; Yang, Haitao
作者单位	1.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Tsinghua Univ, Sch Life Sci, Lab Struct Biol, Beijing, Peoples R China 4.Tsinghua Univ, Sch Med, Beijing, Peoples R China 5.Chinese Acad Sci, Ctr Biosafety Megasci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Peoples R China 6.Tianjin Univ, Sch Life Sci, Tianjin, Peoples R China 7.Cleveland Clin, Taussig Canc Ctr, Cleveland, OH 44106 USA 8.Nankai Univ, Coll Life Sci, Coll Pharm, Frontiers Sci Ctr Cell Response,State Key Lab Med, Tianjin, Peoples R China 9.Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia
第一作者单位	免疫化学研究所; 生命科学与技术学院
通讯作者单位	免疫化学研究所; 生命科学与技术学院
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Jin, Zhenming,Zhao, Yao,Sun, Yuan,et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY,2020,27(6):529-532.
APA	Jin, Zhenming.,Zhao, Yao.,Sun, Yuan.,Zhang, Bing.,Wang, Haofeng.,...&Rao, Zihe.(2020).Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.NATURE STRUCTURAL & MOLECULAR BIOLOGY,27(6),529-532.
MLA	Jin, Zhenming,et al."Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur".NATURE STRUCTURAL & MOLECULAR BIOLOGY 27.6(2020):529-532.