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Salience processing by glutamatergic neurons in the ventral pallidum | |
2020-03-15 | |
发表期刊 | SCIENCE BULLETIN |
ISSN | 2095-9273 |
EISSN | 2095-9281 |
卷号 | 65期号:5页码:389-401 |
发表状态 | 已发表 |
DOI | 10.1016/j.scib.2019.11.029 |
摘要 | Organisms must make sense of a constant stream of sensory inputs from both internal and external sources which compete for attention by determining which ones are salient. The ability to detect and respond appropriately to potentially salient stimuli in the environment is critical to all organisms. However, the neural circuits that process salience are not fully understood. Here, we identify a population of glutamatergic neurons in the ventral pallidum (VP) that play a unique role in salience processing. Using cell-type-specific fiber photometry, we find that VP glutamatergic neurons are robustly activated by a variety of aversion- and reward-related stimuli, as well as novel social and non-social stimuli. Inhibition of the VP glutamatergic neurons reduces the ability to detect salient stimuli in the environment, such as aversive cue, novel conspecific and novel object. Besides, VP glutamatergic neurons project to both the lateral habenula (LHb) and the ventral tegmental area (VTA). Together, our findings demonstrate that the VP glutamatergic neurons participate in salience processing and therefore provide a new perspective on treating several neuropsychiatric disorders, including dementia and psychosis. (C) 2019 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. |
关键词 | Salience Ventral pallidum (VP) Glutamate Aversion Reward Novelty |
收录类别 | SCI ; SCIE ; EI ; CSCD |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[31922029] ; National Natural Science Foundation of China[31671086] ; National Natural Science Foundation of China[61890951] ; National Natural Science Foundation of China[61890950] ; National Natural Science Foundation of China[31700909] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000518396800010 |
出版者 | ELSEVIER |
WOS关键词 | EFFERENT CONNECTIONS ; REWARD ; HABENULA ; ROLES |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/119024 |
专题 | iHuman研究所_PI研究组_孙文智组 生命科学与技术学院_PI研究组_胡霁组 生命科学与技术学院_公共科研平台_分子影像平台 生命科学与技术学院_博士生 |
通讯作者 | Sun, Wenzhi; Hu, Ji |
作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Columbia Univ, New York, NY 10027 USA 5.ShanghaiTech Univ, iHuman Inst, Shanghai 201210, Peoples R China 6.Chinese Inst Brain Res, Beijing 102206, Peoples R China 7.Capital Med Univ, Sch Basic Med Sci, Beijing 100069, Peoples R China 8.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Peoples R China |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
第一作者的第一单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Wang, Fang,Zhang, Juen,Yuan, Yuan,et al. Salience processing by glutamatergic neurons in the ventral pallidum[J]. SCIENCE BULLETIN,2020,65(5):389-401. |
APA | Wang, Fang.,Zhang, Juen.,Yuan, Yuan.,Chen, Ming.,Gao, Zilong.,...&Hu, Ji.(2020).Salience processing by glutamatergic neurons in the ventral pallidum.SCIENCE BULLETIN,65(5),389-401. |
MLA | Wang, Fang,et al."Salience processing by glutamatergic neurons in the ventral pallidum".SCIENCE BULLETIN 65.5(2020):389-401. |
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