Site-directed RNA editing (SDRE): Off-target effects and their countermeasures

doi:10.1016/j.jgg.2019.11.005

	Site-directed RNA editing (SDRE): Off-target effects and their countermeasures
	Mao, Shaoshuai1,2,3 ; Liu, Yajing1,2,3 ; Huang, Shisheng1,2,3 ; Huang, Xingxu1 ; Chi, Tian1,4
	2019-11-20
发表期刊	JOURNAL OF GENETICS AND GENOMICS (IF:6.6[JCR-2023],5.8[5-Year])
ISSN	1673-8527
EISSN	1873-5533
卷号	46 期号:11 页码:531-535
发表状态	已发表
DOI	10.1016/j.jgg.2019.11.005
摘要	Site-directed RNA editing (SDRE) is invaluable to basic research and clinical applications and has emerged as a new frontier in genome editing. The past few years have witnessed a surge of interest in SDRE, with SDRE tools emerging at a breathtaking pace. However, off-target effects of SDRE remain a tough problem, which constitutes a major hurdle to their clinical applications. Here we discuss the diverse strategies for combating off-target editing, drawing lessons from the published studies as well as our ongoing research. Overall, SDRE is still at its infancy, with significant challenges and exciting opportunities ahead. Copyright (C) 2019, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
关键词	Gene editing RNA editing Cas13 Off-target Specificity
收录类别	SCI ; SCIE
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS记录号	WOS:000509466100004
出版者	SCIENCE PRESS
WOS关键词	MUTATIONS ; DISEASE
原始文献类型	Review
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/105295
专题	生命科学与技术学院_硕士生生命科学与技术学院_PI研究组_池天组生命科学与技术学院_PI研究组_黄行许组生命科学与技术学院_博士生
通讯作者	Chi, Tian
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yale Univ, Sch Med, Dept Immunobiol, 333 Cedar St, New Haven, CT 06520 USA
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Mao, Shaoshuai,Liu, Yajing,Huang, Shisheng,et al. Site-directed RNA editing (SDRE): Off-target effects and their countermeasures[J]. JOURNAL OF GENETICS AND GENOMICS,2019,46(11):531-535.
APA	Mao, Shaoshuai,Liu, Yajing,Huang, Shisheng,Huang, Xingxu,&Chi, Tian.(2019).Site-directed RNA editing (SDRE): Off-target effects and their countermeasures.JOURNAL OF GENETICS AND GENOMICS,46(11),531-535.
MLA	Mao, Shaoshuai,et al."Site-directed RNA editing (SDRE): Off-target effects and their countermeasures".JOURNAL OF GENETICS AND GENOMICS 46.11(2019):531-535.