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Benchmarking copy number aberrations inference tools using single-cell multi-omics datasets
预印本
2025
Authors:
Song, Minfang
;
Ma, Shuai
;
Wang, Gong
;
Wang, Yukun
;
Yang, Zhenzhen
Adobe PDF(2429Kb)
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View/Download:423/7
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Submit date:2024/10/14
single-cell RNA sequencing
copy number aberrations
copy number alteration
copy number variations
loss of heterozygosity
single cell multi-omics
An upgraded nuclease prime editor platform enables high-efficiency singled or multiplexed knock-in/knockout of genes in mouse and sheep zygotes
期刊论文
PROTEIN & CELL, 2025
Authors:
Mao, Weijia
;
Wang, Pei
;
Zhou, Lei
;
Li, Dongxu
;
Li, Xiangyang
Adobe PDF(1142Kb)
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View/Download:43/3
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Submit date:2025/03/25
Perillaldehyde Improves Parkinson-Like Deficits by Targeting G3BP Mediated Stress Granule Assembly in Preclinical Models
期刊论文
ADVANCED SCIENCE, 2025
Authors:
Fang, Minglv
;
Luo, Lingling
;
Chen, Youjia
;
Liu, Ying
;
Yan, Yingxuan
Adobe PDF(8118Kb)
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View/Download:90/4
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Submit date:2025/03/03
alpha-synuclein
G3BP
histone deacetylase 6
liquid-liquid phase separation
Parkinson's disease
perillaldehyde
stress granules
Unveiling the Evolution of Antimicrobial Peptides in Gut Microbes via Foundation Model-Powered Framework
预印本
2025
Authors:
Li, Wenhui
;
Huang, Baicheng
;
Guo, Menghao
;
Zeng, Zihan
;
Cai, Tao
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  |  
View/Download:57/0
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Submit date:2025/03/10
Developing safe and efficient CGBE editor based on Cas-embedding strategy
期刊论文
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2025, 卷号: 10, 期号: 2
Authors:
Lin, Tian
;
Wang, Xin
;
Zhang, Yu
;
Li, Guanglei
;
Huang, Xingxu
Adobe PDF(4784Kb)
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View/Download:70/2
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Submit date:2025/03/03
CGBE
Cas-embedding
Off-target
eA3A
Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis
期刊论文
EMBO JOURNAL, 2024, 卷号: 43, 期号: 24
Authors:
Li, Zhean
Adobe PDF(5941Kb)
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Submit date:2025/02/12
Innate Immunity
Deaminases
SARS-CoV-2
Deaminases
Mutagenesis
Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3a
期刊论文
CELL DISCOVERY, 2024, 卷号: 10, 期号: 1
Authors:
Liu, Yajing
;
Lou, Sensen
;
Li, Jinhui
;
Liu, Yuanhua
;
Huang, Shisheng
Adobe PDF(1307Kb)
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Submit date:2024/09/30
Epigenomic landscapes during prefrontal cortex development and aging in rhesus
期刊论文
NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 8
Authors:
Ning, Chao
;
Wu, Xi
;
Zhao, Xudong
;
Lu, Zongyang
;
Yao, Xuelong
Adobe PDF(3955Kb)
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Submit date:2024/09/02
rhesus macaque
prefrontal cortex
3D genomics
chromatin immunoprecipitation sequencing
development
aging
用于提高碱基编辑精度的融合蛋白
专利
申请号:CN202410663572.1,申请日期: 2024-08-02,类型:发明申请,状态:实质审查
Inventors:
陈佳
;
黄行许
;
杨力
;
杨贝
;
李潇飒
Adobe PDF(7832Kb)
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View/Download:320/1
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Submit date:2024/08/02
Zero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
期刊论文
CELL RESEARCH, 2024
Authors:
Cheng, Peng
;
Mao, Cong
;
Tang, Jin
;
Yang, Sen
;
Cheng, Yu
Adobe PDF(5347Kb)
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View/Download:395/3
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Submit date:2024/07/22