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The structural basis of the G protein–coupled receptor and ion channel axis
期刊论文
CURRENT RESEARCH IN STRUCTURAL BIOLOGY, 2025
作者:
Luo YL(罗煜林)
;
Sun LP(孙立萍)
;
Peng Y(彭瑶)
Adobe PDF(2148Kb)
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浏览/下载:29/4
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提交时间:2025/04/04
Sensory neurons and GPCRs (G protein-coupled receptors) and ion channels and signal transduction and structural biology
Rational design of functional amyloid fibrillar assemblies
期刊论文
CHEMICAL SOCIETY REVIEWS, 2023, 卷号: 52, 期号: 14, 页码: 4603-4631
作者:
Wang, Xinyu
;
Zhang, Shengnan
;
Zhang, Jicong
;
Wang, Yaomin
;
Jiang, Xiaoyu
Adobe PDF(6747Kb)
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收藏
|
浏览/下载:264/1
|
提交时间:2023/07/11
Biomimetics
Functional materials
Glycoproteins
Neurodegenerative diseases
Structural properties
Viruses
Biological functions
Design Principles
Environmental stability
Hierarchical assemblies
Living organisms
Rational design
Self-healing properties
Synthetic biology
Typical application
Unique features
Exploring and Learning the Universe of Protein Allostery Using Artificial Intelligence Augmented Biophysical and Computational Approaches
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2023, 卷号: 63, 期号: 5, 页码: 1413-1428
作者:
Agajanian, Steve
;
Alshahrani, Mohammed
;
Bai, Fang
;
Tao, Peng
;
Verkhivker, Gennady M.
Adobe PDF(7617Kb)
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浏览/下载:463/1
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提交时间:2023/03/28
biology drug allosteric mechanisms
artificial intelligence
protein allostery
first principles
high-throughput deep mutational scanning
allosteric drug design
machine learning
structural prediction methods
SARS-CoV-2
Subtle change of fibrillation condition leads to substantial alteration of recombinant Tau fibril structure
期刊论文
ISCIENCE, 2022, 卷号: 25, 期号: 12, 页码: 105645
作者:
Li, Xiang
;
Zhang, Shenqing
;
Liu, Zhengtao
;
Tao, Youqi
;
Xia, Wencheng
Adobe PDF(3119Kb)
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浏览/下载:314/6
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提交时间:2023/02/03
cell biology
Neuroscience
structural biology
Filamentation modulates allosteric regulation of PRPS
期刊论文
ELIFE, 2022, 卷号: 11
作者:
Hu, Huan-Huan
;
Lu, Guang-Ming
;
Chang, Chia-Chun
;
Li, Yilan
;
Zhong, Jiale
Adobe PDF(17288Kb)
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收藏
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浏览/下载:615/2
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提交时间:2022/07/21
PRPS
cytoophidium
allosteric regulation
Cryo-EM
E.coli
structural biology
Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Wu, Can-rong
;
Yin, Wan-chao
;
Jiang, Yi
;
Xu, H. Eric
Adobe PDF(4109Kb)
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浏览/下载:626/191
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提交时间:2022/02/11
COVID-19
SARS-CoV-2
structural biology
omicron
drug design
vaccine development
Structure-Activity Relationship Studies of Hydantoin-Cored Ligands for Smoothened Receptor
期刊论文
CHEMISTRYOPEN, 2021, 卷号: 10, 期号: 10, 页码: 1028-1032
作者:
Liu, Yang
;
Zhou, Fang
;
Ding, Kang
;
Xue, Dongxiang
;
Zhu, Zhihao
Adobe PDF(889Kb)
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浏览/下载:632/5
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提交时间:2021/12/03
anti-cancer
halogen bonding
molecular dynamics
smoothened receptor
structural biology
The structural basis for glycerol permeation by human AQP7
期刊论文
SCIENCE BULLETIN, 2021, 卷号: 66, 期号: 15, 页码: 1550-1558
作者:
Zhang, Li
;
Yao, Deqiang
;
Xia, Ying
;
Zhou, Fu
;
Zhang, Qing
Adobe PDF(2253Kb)
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收藏
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浏览/下载:307/0
|
提交时间:2021/08/27
Glycerol transportation
Aquaglyceroporins
Glycerol metabolism
Structural biology
Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325
作者:
Chang, Rulue
;
Zhang, Xin
;
Qiao, Anna
;
Dai, Antao
;
Belousoff, Matthew J.
Adobe PDF(2565Kb)
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收藏
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浏览/下载:274/0
|
提交时间:2022/12/09
Electron microscopy
Medical imaging
Electron microscopes
Amino acids
Bound structure
Conformational dynamics
Cryo-electron microscopy
Extracellular domains
Extracellular loops
Glucagon-like peptide-1
Metabolic disease
Transmembrane segments
glucagon receptor
glucagon-like peptide-1 receptor
dual agonist
cryo-electron microscopy
single particle analysis
structure-function
structural biology
peptide 15 (P15)
metabolic disorder
G protein?coupled receptor (GPCR)
glucagon
GLP-1 receptor
The structural biology of the shelterin complex
期刊论文
BIOLOGICAL CHEMISTRY, 2019, 卷号: 400, 期号: 4, 页码: 457-466
作者:
Chen, Yong
Adobe PDF(1118Kb)
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浏览/下载:595/6
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提交时间:2019/03/31
DNA binding
protein-protein interaction
shelterin complex
structural biology
telomere
telomeric protein
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