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合作作者[TOP 5]

  • Lei, Ming

    合作成果数：8

  • Xu, Ying

    合作成果数：7

  • Hu, Chunyi

    合作成果数：5

  • Kanoh, Junko

    合作成果数：5

  • Li, Yanjing

    合作成果数：5
陈勇 中科院特聘教授
所在学院： 生命科学与技术学院
职务： --
研究方向： 结构生物学（中科院上海生命科学研究院生物化学与细胞生物学研究所研究员）
备注： --
陈勇

研究内容

实验室聚焦于重要表观遗传因子的结构生物学研究。拟对一些关键的表观遗传因子复合物利用结构生物学和生物化学的手段进行深入的研究，以揭示其活性机制、调节机理和设计针对其特定结构靶点的药物小分子。具体研究内容包括: 揭示依赖ATP的染色体重塑复合物的分子作用机制；阐明依赖ATP的染色体重塑与组蛋白修饰之间的协同作用机制； 阐析端粒染色体组装的分子机制。

科研成果

25 12986 2070 807 0 14
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 [1] Weng, Yue.,Yan, Xiangyu.,Chen, Biying.,Bian, Zhouliang.,Ge, Yunhui.,...&Zhang, Yanjie.(2025).PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma.GENES & DISEASES,12(2).浏览/下载:278/1; 被引[WOS]:0; IF:6.9/7.2评论推荐收藏
 [2] Sun, Wenqi.,Dong, Qianhua.,Li, Xueqing.,Gao, Jinxin.,Ye, Xianwen.,...&Chen, Yong.(2024).The SUN-family protein Sad1 mediates heterochromatin spatial organization through interaction with histone H2A-H2B.NATURE COMMUNICATIONS,15(1).浏览/下载:261/67; 被引[WOS]:0; IF:14.7/16.1评论推荐收藏
 [3] Rai, Rekha.,Biju, Kevin.,Sun, Wenqi.,Sodeinde, Tori.,Al-Hiysat, Amer.,...&Chang, Sandy.(2023).Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2(B) and RAP1.NATURE COMMUNICATIONS,14(1).浏览/下载:1204/277; 被引[WOS]:12; IF:14.7/16.1评论推荐收藏
 [4] Liang, Lujie,Zhong, Lan-Lan,Wang, Lin,et al. Identification of a novel MCR-1 variant displaying low level of co-resistance to β-lactam antibiotics that uncovers a potential novel antimicrobial peptide. 2023.浏览/下载:278/0; 被引[WOS]:0评论推荐收藏
 [5] Li, Yanjing.,Zhao, Lijie.,Zhang, Yuebin.,Wu, Ping.,Xu, Ying.,...&Chen, Yong.(2022).Structural basis for product specificities of MLL family methyltransferases.MOLECULAR CELL,82(20).浏览/下载:400/1; 被引[WOS]:9; IF:14.5/16.6评论推荐收藏
 [6] Zhao, Lijie.,Huang, Naizhe.,Mencius, Jun.,Li, Yanjing.,Xu, Ying.,...&Chen, Yong.(2022).DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates.ISCIENCE,25(9).浏览/下载:412/0; 被引[WOS]:4; IF:4.6/5.0评论推荐收藏
 [7] Wang, Duo.,Yan, Fuxiang.,Wu, Ping.,Ge, Kexue.,Li, Muchun.,...&Chen, Yong.(2022).Global profiling of regulatory elements in the histone benzoylation pathway.NATURE COMMUNICATIONS,13(1).浏览/下载:445/0; 被引[WOS]:13; IF:14.7/16.1评论推荐收藏
 [8] Hu, Chunyi,Inoue, Haruna,Sun, Wenqi,et al. Structural Insights Into Chromosome Attachment To The Nuclear Envelope By An Inner Nuclear Membrane Protein Bqt4 In Fission Yeast (vol 47, Pg 1573, 2019). 2021-12-02.浏览/下载:396/0; 被引[WOS]:0评论推荐收藏
 [9] Zheng, Yongxin.,Huang, Yinping.,Mencius, Jun.,Li, Yanjing.,Zhao, Lijie.,...&Quan, Shu.(2021).Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes.JOURNAL OF BIOLOGICAL CHEMISTRY,296.浏览/下载:238/0; 被引[WOS]:7; IF:4.0/4.4评论推荐收藏
 [10] Yanjing Li,Lijie Zhao,Xiaoxu Tian,Peng Chao,Fan Gong,&Yong Chen.(2020).Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.STRUCTURE,28(10),1141-+.浏览/下载:346/0; 被引[WOS]:17; IF:4.4/4.3评论推荐收藏