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ShanghaiTech University Knowledge Management System
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Rational Design of a Triple Tumor Microenvironment-Responsive Nanoplatform for Enhanced Tumor Theranostics
期刊论文
CHEMISTRY - A EUROPEAN JOURNAL, 2023
作者:
Zhang, Shouqiang
;
Han, Xin
;
Chen, Xinran
;
Liu, Yuxin
;
Zhou, Jing
Adobe PDF(2523Kb)
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收藏
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浏览/下载:286/0
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提交时间:2022/12/30
Absorbance
Controlled drug delivery
Diagnosis
Drug products
Fluorescence
Peptides
Rare earths
Targeted drug delivery
Tumors
Antitumour agents
Cancer * antitumor agent * TME-responsive * nanoplatform * synergistic therapy
Epigallocatechin gallate
Layered-double hydroxides
Ni 2
Peptide-chain
Rational design
Tumor microenvironments
Tumour cells
Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway
期刊论文
RESEARCH, 2023, 卷号: 6
作者:
Jiang, Yu
;
Li, Xiyuan
;
Qian, Fenghui
;
Sun, Bingbing
;
Wang, Xiyuan
Adobe PDF(1153Kb)
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收藏
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浏览/下载:652/1
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提交时间:2023/04/21
Antibiotics
Chemical activation
Escherichia coli
Mammals
Tumors
Adenosine monophosphate
Antitumor effect
Antitumour activity
Biological approach
Fine tuning
Immune activation
In-vitro
Innate immunes
Nissle 1917
Tumor therapy
Microvesicle-inspired oxygen-delivering nanosystem potentiates radiotherapy-mediated modulation of tumor stroma and antitumor immunity
期刊论文
BIOMATERIALS, 2022, 卷号: 290
作者:
Gong, Xiang
;
Li, Jie
;
Xu, Xiaoxuan
;
Wu, Yao
;
Lei, Ying
Adobe PDF(19977Kb)
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浏览/下载:405/0
|
提交时间:2022/11/04
Cancer cells
Cell culture
Diseases
Nanosystems
Oxygen
Oxygenation
Tumors
Anti-tumor immune
Anti-tumor immune response
Antitumor immunity
Halofuginone
Immune response
Microenvironments
Microvesicles
Tumor hypoxia
Tumor oxygenation
Tumor-stroma
ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity
期刊论文
NANO LETTERS, 2022
作者:
Wang, Jiaoying
;
Li, Jie
;
Wu, Yao
;
Xu, Xiaoxuan
;
Qian, Xindi
Adobe PDF(7870Kb)
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收藏
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浏览/下载:317/1
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提交时间:2022/11/04
Diseases
Interferons
Radiotherapy
T-cells
Tumors
Antitumor immunity
Cabazitaxel
Death-receptor
Nanocomplexes
PD-l1
Reactive oxygen species
Reactive oxygen species-responsive
Receptor ligands
Tumor models
Tumor penetration
Design, synthesis and biological evaluation of novel osimertinib derivatives as reversible EGFR kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 238
作者:
Ding, Shi
;
Gao, Ziye
;
Hu, Ziqiang
;
Qi, Rui
;
Zheng, Xiangshan
Adobe PDF(8843Kb)
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浏览/下载:368/0
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提交时间:2022/08/15
Osimertinib derivatives
Reversible EGFR kinase Inhibitors
L858R/T790M/C797S mutation
Antitumor activity
Docking study
Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Zhou, Jing-yi
;
Yang, Rui-rui
;
Chang, Jie
;
Song, Jia
;
Fan, Zi-sheng
Adobe PDF(4057Kb)
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收藏
|
浏览/下载:321/0
|
提交时间:2022/08/23
Bcl-2
BH4 domain
apoptosis
antitumor
virtual screening
Design, synthesis and biological evaluation of novel N-(3-amino-4-methoxyphenyl)acrylamide derivatives as selective EGFR(L858R/T790M) kinase inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2022, 卷号: 118
作者:
Ding, Shi
;
Dong, Xiaoyong
;
Gao, Ziye
;
Zheng, Xiangshan
;
Ji, Jingchao
Adobe PDF(8618Kb)
|
收藏
|
浏览/下载:225/0
|
提交时间:2022/08/15
N-(3-amino-4-methoxyphenyl)acrylamide derivatives
EGFR-TKIs
Kinase selectivity
Antitumor activity
Docking study
Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction
期刊论文
ARCHIV DER PHARMAZIE, 2020
作者:
Xiao, Donghuai
;
Wang, Yu-jie
;
Wang, Han-lin
;
Zhou, Yu-bo
;
Li, Jia
Adobe PDF(1428Kb)
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收藏
|
浏览/下载:332/0
|
提交时间:2020/05/14
antitumor
arylboronic acid
lenalidomide
Suzuki cross-coupling
Design and synthesis of Imidazo[1,2-b]pyridazine IRAK4 inhibitors for the treatment of mutant MYD88 L265P diffuse large B-cell lymphoma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 190
作者:
Chen, Yun
;
Bai, Gang
;
Ning, Yi
;
Cai, Shi
;
Zhang, Tao
Adobe PDF(1964Kb)
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收藏
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浏览/下载:330/0
|
提交时间:2020/04/12
lnterleukin-1 receptor associated kinase 4
Imidazol1,2-6]pyridazine
Diffuse large B-cell lymphoma
Drug design
Antitumor agents
Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 卷号: 57, 期号: 30, 页码: 9284-9289
作者:
Zhu, Dongsheng
;
Guo, Haijun
;
Chang, Yu
;
Ni, Yun
;
Li, Lin
Adobe PDF(6229Kb)
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收藏
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浏览/下载:457/2
|
提交时间:2018/08/09
affinity-based probes
antitumor agents
apoptosis biomarkers
combination drugs
target identification
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