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成果统计

合作作者[TOP 5]

  • Xu, Lei

    合作成果数：5

  • Zhou, Yu-bo

    合作成果数：5

  • Gao, An-hui

    合作成果数：4

  • Li, Jing-Ya

    合作成果数：4

  • Zhou, Yubo

    合作成果数：4
李佳 中科院特聘教授
所在学院： 生命科学与技术学院
职务： 上海药物所副所长
研究方向： 新药筛选（中科院上海药物研究所研究员）
备注： --
李佳

研究内容

针对能量代谢调控的关键分子及相关信号网络进行活性调控机制研究；围绕糖尿病、神经退行性疾病、肿瘤等重大疾病，系统化克隆、表达、纯化和基因转染相关分子靶点，建立分子家族筛选平台和疾病靶向组合筛选模型平台；通过高通量筛选发现先导化合物；研究先导化合物和靶标相互作用模式；研究活性化合物作用机制、发现新靶点。

科研成果

16 7544 1330 927 0 10
Items Views Downloads TC[WOS] TC[CSCD] H-index
排序方式：
 [1] Jiang, Kai-long,Liu, Chang-mei,Nie, Li-tong,et al. Discovery Of Toxoflavin, A Potent Ire1a Inhibitor Acting Through Structure-dependent Oxidative Inhibition (vol 44, 234, 2023). 2023-08-01.浏览/下载:409/114; 被引[WOS]:0评论推荐收藏
 [2] Xu, Lei.,Xuyan, Xuyang.,Minmi, Minmin.,Wang, Zhiji.,Shee, Chao.,...&Wang, Wenlong.(2023).Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors.CHINESE CHEMICAL LETTERS,34(8).浏览/下载:365/0; 被引[WOS]:16; IF:9.4/7.3评论推荐收藏
 [3] Li, Teng-teng.,Peng, Cheng.,Wang, Ji-qiu.,Xu, Zhi-jian.,Su, Ming-bo.,...&Li, Jing-ya.(2022).Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain.ACTA PHARMACOLOGICA SINICA.浏览/下载:775/247; 被引[WOS]:5; IF:6.9/7.6评论推荐收藏
 [4] Jiang, Kai-long.,Liu, Chang-mei.,Nie, Li-tong.,Jiang, Hai-ni.,Xu, Lei.,...&Li, Jia.(2022).Discovery of toxoflavin, a potent IRE1 alpha inhibitor acting through structure-dependent oxidative inhibition.ACTA PHARMACOLOGICA SINICA.浏览/下载:333/0; 被引[WOS]:5; IF:6.9/7.6评论推荐收藏
 [5] Jiang, Kai-long.,Tong, Le-xian.,Wang, Tao.,Wang, Han-lin.,Hu, Xiao-bei.,...&Li, Jia.(2022).Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies.ACTA PHARMACOLOGICA SINICA.浏览/下载:392/1; 被引[WOS]:7; IF:6.9/7.6评论推荐收藏
 [6] Han, Xu.,Song, Ning.,Saidahmatov, Abdusaid.,Wang, Peipei.,Wang, Yong.,...&Wang, Jiang.(2021).Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.JOURNAL OF MEDICINAL CHEMISTRY,64(19),14647-14663.浏览/下载:518/0; 被引[WOS]:16; IF:6.8/7.1评论推荐收藏
 [7] Zhang, Xiao-tuan.,Hu, Xiao-bei.,Wang, Han-lin.,Kan, Wei-juan.,Xu, Lei.,...&Li, Jia.(2021).Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma.ACTA PHARMACOLOGICA SINICA.浏览/下载:295/0; 被引[WOS]:7; IF:6.9/7.6评论推荐收藏
 [8] Yang, Xiangbo.,Wang, Zhijia.,Pei, Yuan.,Song, Ning.,Xu, Lei.,...&Zhou, Bing.(2021).Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,218.浏览/下载:303/0; 被引[WOS]:57; IF:6.0/6.1评论推荐收藏
 [9] Xiao, Donghuai.,Wang, Yu-jie.,Wang, Han-lin.,Zhou, Yu-bo.,Li, Jia.,...&Jin, Jiyu.(2020).Design and synthesis of new lenalidomide analogs via Suzuki cross-coupling reaction.ARCHIV DER PHARMAZIE.浏览/下载:317/0; 被引[WOS]:9; IF:4.3/4.4评论推荐收藏
 [10] Tong, Lexian.,Song, Pinrao.,Jiang, Kailong.,Xu, Lei.,Jin, Tingting.,...&Hu, Yongzhou.(2019).Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,173,44-62.浏览/下载:604/12; 被引[WOS]:19; IF:6.0/6.1评论推荐收藏