ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity

doi:10.1021/acs.nanolett.2c03227

	ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity
	Wang, Jiaoying 1,2; Li, Jie 2; Wu, Yao 4; Xu, Xiaoxuan 2; Qian, Xindi 2; Lei, Ying5 ; Liu, Huanzhen5 ; Zhang, Zhiwen 4; Li, Yaping 1,2,3
	2022-10-26
发表期刊	NANO LETTERS (IF:9.6[JCR-2023],10.1[5-Year])
ISSN	1530-6984
EISSN	1530-6992
DOI	10.1021/acs.nanolett.2c03227
摘要	Despite the promising benefits of immune checkpoint inhibitors (ICIs) in clinical cancer treatments, the therapeutic efficacy is largely restricted by low antitumor immunity and limited intratumor delivery in solid tumors. Herein, we designed a reactive oxygen species (ROS)-responsive albumin nanocomplex of antiprogrammed cell death receptor ligand 1 (aPD-L1) and cabazitaxel (RAN-PC), which exhibited prominent tumor accumulation and intratumor permeation in 4T1 tumors. Compared with the negative control, the RAN-PC + radiation treatment (RAN-PC+X) produced a 3.61- and 5.10-fold enhancement in CD3+CD8+ T cells and the interferon (IFN)-γ-expressing subtype, respectively, and notably reduced versatile immunosuppressive cells. Moreover, RAN-PC+X treatment resulted in notable retardation of tumor growth, with a 78.97% inhibition in a 4T1 breast tumor model and a 90.30% suppression in a CT-26 colon tumor model. Therefore, the ROS-responsive albumin nanocomplex offers an encouraging platform for ICIs with prominent intratumor delivery capacity for cancer immunotherapy. © 2022 American Chemical Society.
关键词	Diseases Interferons Radiotherapy T-cells Tumors Antitumor immunity Cabazitaxel Death-receptor Nanocomplexes PD-l1 Reactive oxygen species Reactive oxygen species-responsive Receptor ligands Tumor models Tumor penetration
收录类别	EI ; SCIE
语种	英语
出版者	American Chemical Society
EI入藏号	20224313005671
EI主题词	Cell death
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.6 Medicine and Pharmacology ; 461.9 Biology ; 461.9.1 Immunology ; 622.3 Radioactive Material Applications
原始文献类型	Article in Press
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/241108
专题	免疫化学研究所_公共科研平台_高通量筛选平台
通讯作者	Zhang, Zhiwen; Li, Yaping
作者单位	1.School of Environmental Chemistry and Engineering, Shanghai University, Shanghai; 200444, China; 2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai; 201203, China; 3.Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Shandong, Yantai; 264117, China; 4.School of Pharmacy, Key Laboratory of Smart Drug Delivery (Ministry of Education), Fudan University, Shanghai; 201203, China; 5.Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai; 201210, China
推荐引用方式 GB/T 7714	Wang, Jiaoying,Li, Jie,Wu, Yao,et al. ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity[J]. NANO LETTERS,2022.
APA	Wang, Jiaoying.,Li, Jie.,Wu, Yao.,Xu, Xiaoxuan.,Qian, Xindi.,...&Li, Yaping.(2022).ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity.NANO LETTERS.
MLA	Wang, Jiaoying,et al."ROS-Responsive Nanocomplex of aPD-L1 and Cabazitaxel Improves Intratumor Delivery and Potentiates Radiation-Mediated Antitumor Immunity".NANO LETTERS (2022).