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The structural basis of the G protein–coupled receptor and ion channel axis
期刊论文
CURRENT RESEARCH IN STRUCTURAL BIOLOGY, 2025
作者:
Luo YL(罗煜林)
;
Sun LP(孙立萍)
;
Peng Y(彭瑶)
Adobe PDF(2148Kb)
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浏览/下载:47/8
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提交时间:2025/04/04
Sensory neurons and GPCRs (G protein-coupled receptors) and ion channels and signal transduction and structural biology
Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux
期刊论文
AUTOPHAGY, 2025
作者:
Ding Ning
;
Song Yijie
;
Zhang Yuhang
;
Yu Wei
;
Li Xinnan
Adobe PDF(10720Kb)
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浏览/下载:85/4
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提交时间:2025/03/05
Autophagy receptors
CGG repeat expansions
HSPB1
p62
poly-glycine
RAN translation
A PRA-Rab trafficking machinery modulates NLR immune receptor plasma membrane microdomain anchoring and blast resistance in rice
期刊论文
SCIENCE BULLETIN, 2025, 卷号: 70, 期号: 5
作者:
Liang, Di
;
Yang, Dongyong
;
Li, Tai
;
Zhu, Zhe
;
Yan, Bingxiao
Adobe PDF(5548Kb)
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浏览/下载:57/0
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提交时间:2025/02/12
Anchorings
Immune receptors
Immune response
Leucine-rich repeats
Membrane microdomains
Nucleotide binding
Osrab5a
Pigmr
Prenylated rab acceptor
Trafficing vesicle
Inhibitor Development for α‑Synuclein Fibril's Disordered Region to Alleviate Parkinson's Disease Pathology
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 41, 页码: 28282-28295
作者:
Zhang, Shenqing
;
Xiang, Huaijiang
;
Tao, Youqi
;
Li, Juan
;
Zeng, Shuyi
Adobe PDF(12245Kb)
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浏览/下载:361/12
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提交时间:2024/09/27
Neurodegenerative diseases
Nuclear magnetic resonance spectroscopy
Targeted drug delivery
Amyloid fibril
Disordered regions
EM techniques
High throughput screening
Intrinsically disordered regions
Membrane receptors
Pathological effects
Solid state NMR
Structure-activity relationships
α-synuclein
Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 29, 页码: 20045-20058
作者:
Liu, Hongyue
;
Yan, Pengfei
;
Zhang, Zhaoyu
;
Han, Hongbo
;
Zhou, Qingtong
Adobe PDF(7016Kb)
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浏览/下载:455/12
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提交时间:2024/08/09
Activation analysis
Chemical activation
Ligands
Proteins
'current
G protein
G protein coupled receptors
Limited proteolysis
Multiple domains
Receptor activation
Receptor signaling
Structural mass
Structural snapshots
Structural studies
Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception
期刊论文
NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 7
作者:
Dou, Yan-Nong
;
Liu, Yuan
;
Ding, Wen-Qun
Adobe PDF(3293Kb)
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浏览/下载:263/44
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提交时间:2024/08/09
Brain
Chemical activation
Electric network analysis
Electrophysiology
Timing circuits
Antinociception
Central amygdala nucleus
Endogenous opioid antinociception
Hyperalgesia
Mu-opioid receptor
Opioid receptors
Opioids
Parabrachial nucleus
Single neuron
Single-neuron projectome
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrL
Glu
activity
期刊论文
ACTA PHARMACOLOGICA SINICA, 2024
作者:
Ma, Jian-chi
;
Che, Xiao-hang
;
Zhu, Xiao-na
;
Ren, Ao-xin
;
Hu, Yue
Adobe PDF(4033Kb)
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浏览/下载:257/1
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提交时间:2024/07/08
cognitive deficits
methamphetamine
object recognition memory
memory retrieval impairment
prelimbic cortex
D2 receptors
A Label Disambiguation-Based Multimodal Massive Multiple Instance Learning Approach for Immune Repertoire Classification
会议论文
PROCEEDINGS OF THE AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE, Vancouver, BC, Canada, February 20, 2024 - February 27, 2024
作者:
Xu, Fan
;
Zhao, Yu
;
Wu, Bingzhe
;
Huang, Yueshan
;
Ren, Qin
Adobe PDF(1229Kb)
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浏览/下载:376/58
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提交时间:2024/04/26
Artificial intelligence
Learning systems
Computational burden
Computational costs
Fusion modules
Immune receptors
Learning approach
Learning problem
Multi-modal
Multi-modal fusion
Multiple-instance learning
Time points
Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs
期刊论文
SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 6
作者:
Wang, James Jiqi
;
Jin, Sanshan
;
Zhang, Heng
;
Xu, Youwei
;
Hu, Wen
Adobe PDF(2350Kb)
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收藏
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浏览/下载:335/1
|
提交时间:2024/03/08
Blood pressure
Chemical activation
Proteins
Arterial hypertension
Blood pressure regulation
Coupled receptors
Cryo-electron microscopy
G protein
Inflammatory response
Ligand binding
Prostacyclin receptors
Receptor activation
Therapeutic targets
Fenofibrate Recognition and Gq Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1
期刊论文
ADVANCED SCIENCE, 2024, 卷号: 11, 期号: 14
作者:
Wang, Tianxin
;
Tang, Wenqin
;
Zhao, Ziyi
;
Zhao, Ran
;
Lv, Zhenyu
Adobe PDF(4903Kb)
|
收藏
|
浏览/下载:220/13
|
提交时间:2024/09/21
Cryo-electron microscopy
Cannabinoid receptors
Coupling mechanism
Fenofibrate
Electron microscopes
Electron microscopy
Medical imaging
G protein
Gq coupling
Human cannabinoid receptor 1
Human cannabinoid receptors
Ligand recognition
Receptor-1
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