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Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 51
作者:
Xu, Jiuyin
;
Xu, Youwei
;
Hou, Li
;
He, Xinheng
;
Li, Yang
Adobe PDF(9124Kb)
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浏览/下载:115/6
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提交时间:2025/01/13
prostaglandin receptor
DP2
lipid regulation
receptor activation
signal bias
Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 卷号: 146, 期号: 29, 页码: 20045-20058
作者:
Liu, Hongyue
;
Yan, Pengfei
;
Zhang, Zhaoyu
;
Han, Hongbo
;
Zhou, Qingtong
Adobe PDF(7016Kb)
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浏览/下载:418/11
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提交时间:2024/08/09
Activation analysis
Chemical activation
Ligands
Proteins
'current
G protein
G protein coupled receptors
Limited proteolysis
Multiple domains
Receptor activation
Receptor signaling
Structural mass
Structural snapshots
Structural studies
Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception
期刊论文
NATIONAL SCIENCE REVIEW, 2024, 卷号: 11, 期号: 7
作者:
Dou, Yan-Nong
;
Liu, Yuan
;
Ding, Wen-Qun
;
Li, Qing
;
Zhou, Hua
Adobe PDF(3293Kb)
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浏览/下载:229/31
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提交时间:2024/08/09
Brain
Chemical activation
Electric network analysis
Electrophysiology
Timing circuits
Antinociception
Central amygdala nucleus
Endogenous opioid antinociception
Hyperalgesia
Mu-opioid receptor
Opioid receptors
Opioids
Parabrachial nucleus
Single neuron
Single-neuron projectome
Structural basis for activation of somatostatin receptor 5 by cyclic neuropeptide agonists
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 卷号: 121, 期号: 26
作者:
Li, Jingru
;
You, Chongzhao
;
Li, Yang
;
Li, Changyao
;
Fan, Wenjia
Adobe PDF(9327Kb)
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浏览/下载:237/4
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提交时间:2024/07/08
SSTR5
peptide agonists
agonist selectivity
receptor activation
Selection of Leptin Surrogates by a General Phenotypic Screening Method for Receptor Agonists
期刊论文
BIOMOLECULES, 2024, 卷号: 14, 期号: 4
作者:
Wang T(王涛)
;
Xixi Chen
;
Guang Yang
;
Xiaojie Shi
Adobe PDF(1762Kb)
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浏览/下载:471/48
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提交时间:2024/04/28
phenotypic screening
high-throughput screening
cytokine surrogate
receptor agonist
biological receptor activation-dependent cell survival (BRADS)
Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs
期刊论文
SCIENCE ADVANCES, 2024, 卷号: 10, 期号: 6
作者:
Wang, James Jiqi
;
Jin, Sanshan
;
Zhang, Heng
;
Xu, Youwei
;
Hu, Wen
Adobe PDF(2350Kb)
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收藏
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浏览/下载:310/0
|
提交时间:2024/03/08
Blood pressure
Chemical activation
Proteins
Arterial hypertension
Blood pressure regulation
Coupled receptors
Cryo-electron microscopy
G protein
Inflammatory response
Ligand binding
Prostacyclin receptors
Receptor activation
Therapeutic targets
Structural insight into the constitutive activity of human orphan receptor GPR12
期刊论文
SCIENCE BULLETIN, 2023, 卷号: 68, 期号: 1, 页码: 95-104
作者:
Li, Hao
;
Zhang, Jinyi
;
Yu, Yanan
;
Luo, Feng
;
Wu, Lijie
Adobe PDF(3028Kb)
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收藏
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浏览/下载:780/6
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提交时间:2023/03/10
Electron microscopes
Ligands
Proteins
Signal transduction
Adenosine monophosphate
Constitutive activation
Cryo-electron microscopy
Cryo-electron microscopy structure
Cyclic adenosine
Cyclic adenosine monophosphate
G protein coupled receptors
G protein-coupled receptor 12
Orphan receptor
Self-activation
Conformational Dynamics of the Activated GLP-1 Receptor-Gs Complex Revealed by Cross-Linking Mass Spectrometry and Integrative Structure Modeling
期刊论文
ACS CENTRAL SCIENCE, 2023, 卷号: 9, 期号: 5, 页码: 992-1007
作者:
Yuan, Shijia
;
Xia, Lisha
;
Wang, Chenxi
;
Wu, Fan
;
Zhang, Bingjie
Adobe PDF(3395Kb)
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浏览/下载:544/5
|
提交时间:2023/05/19
Amino acids
Dynamics
Proteins
Conformational dynamics
Conformational ensemble
Cross linking
G protein
G protein coupled receptors
Integrative structure
Receptor activation
Receptor complex
Receptor signaling
Structure models
MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1
期刊论文
FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 卷号: 9
作者:
Wu, Yiran
;
Li, Xuanxuan
;
Hua, Tian
;
Liu, Zhi-Jie
;
Liu, Haiguang
Adobe PDF(3371Kb)
|
收藏
|
浏览/下载:970/179
|
提交时间:2022/05/05
cannabinoid receptor
CB1
molecular dynamics simulations
G protein-coupled receptor
activation mechanism
MD
Structural insights into the activation of chemokine receptor CXCR2
期刊论文
FEBS JOURNAL, 2022
作者:
Liu, Kaiwen
;
Shen, Ling
;
Wu, Meng
;
Liu, Zhi-Jie
;
Hua, Tian
Adobe PDF(3608Kb)
|
收藏
|
浏览/下载:696/1
|
提交时间:2021/08/16
activation
chemokine receptor
cryo-EM
CXCL8
CXCR2
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