Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Controlled Release

doi:10.1002/anie.201707164

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	Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Controlled Release
	Mao, Dake 1; Liang, Yajun2 ; Liu, Yamin 1; Zhou, Xianhao2 ; Ma, Jiaqi 1; Jiang, Biao2 ; Liu, Jia2 ; Ma, Da 1
	2017-10-02
发表期刊	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (IF:16.1[JCR-2023],16.2[5-Year])
ISSN	1433-7851
卷号	56 期号:41 页码:12614-12618
发表状态	已发表
DOI	10.1002/anie.201707164
摘要	Stimuli-responsive molecular containers are of great importance for controlled drug delivery and other biomedical applications. A new type of acid labile acyclic cucurbit[n]uril (CB[n]) molecular containers is presented that can degrade and release the encapsulated cargo at accelerated rates under mildly acidic conditions (pH 5.5-6.5). These containers retain the excellent recognition properties of CB[n]-type hosts. A cell culture study demonstrated that the cellular uptake of cargos could be fine-tuned by complexation with different containers. The release and cell uptake of cargo dye was promoted by acidic pH.
关键词	cucurbit[n]uril drug delivery host-guest systems molecular recognition stimuli response
收录类别	SCI ; IC ; EI
语种	英语
资助项目	Natural Science Foundation of China[51503042] ; Natural Science Foundation of China[21672042]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000411810600035
出版者	WILEY-V C H VERLAG GMBH
EI入藏号	20173704147803
EI主题词	Cell culture ; Containers ; Drug delivery ; Medical applications ; Molecular recognition
WOS关键词	DRUG-DELIVERY ; PH ; NANOPARTICLES ; SYSTEM ; DERIVATIVES ; AFFINITY ; POLYMER ; GENE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/9905
专题	免疫化学研究所生命科学与技术学院免疫化学研究所_特聘教授组_抗体化学实验室生命科学与技术学院_硕士生免疫化学研究所_PI研究组_刘佳组
通讯作者	Liu, Jia; Ma, Da
作者单位	1.Fudan Univ, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China 2.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, 99 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Mao, Dake,Liang, Yajun,Liu, Yamin,et al. Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Controlled Release[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(41):12614-12618.
APA	Mao, Dake.,Liang, Yajun.,Liu, Yamin.,Zhou, Xianhao.,Ma, Jiaqi.,...&Ma, Da.(2017).Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Controlled Release.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(41),12614-12618.
MLA	Mao, Dake,et al."Acid-Labile Acyclic Cucurbit[n]uril Molecular Containers for Controlled Release".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.41(2017):12614-12618.