Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques

doi:10.1016/j.copbio.2019.09.002

	Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques
	Li, Shanshan1 ; Shui, Wenqing1,2
	2020
发表期刊	CURRENT OPINION IN BIOTECHNOLOGY
ISSN	18790429
卷号	64 页码:24-31
发表状态	已发表
DOI	10.1016/j.copbio.2019.09.002
摘要	The recent rapid advance of systematic mapping of protein–metabolite interactions (PMIs) in both prokaryotic and eukaryotic cells has been catalyzed by development of innovative and effective proteomics or metabolomics strategies all based on large-scale mass spectrometry (MS) analysis of biomolecules. Both metabolite-centric and protein-centric approaches have been established to profile PMIs in the native cellular matrix treated by specific metabolites or proteins. Here we will review the development and application of versatile MS-based proteomics and metabolomics techniques for global PMI mapping in different species, which lead to the discovery of numerous uncharacterized PMIs that may reveal new interaction-derived functionality. We further discuss the strengths and limitations of different PMI mapping approaches as well as the key elements in MS quantification and data mining for reliable PMI identification. © 2019
关键词	Biomolecules Data mining Mapping Mass spectrometry Proteins ProteomicsCellular matrix Development and applications Eukaryotic cells Key elements Metabolomics Systematic mapping
收录类别	SCIE ; EI
资助项目	ShanghaiTech University[] ; National Basic Research Program of China (973 Program)[2018YFA0507004] ; National Natural Science Foundation of China[31971362]
出版者	Elsevier Ltd
EI入藏号	20194107518362
EI主题词	Biomolecules ; Data mining ; Mapping ; Mass spectrometry ; Proteins
EI分类号	Surveying:405.3 ; Data Processing and Image Processing:723.2 ; Chemistry:801 ; Biochemistry:801.2 ; Organic Compounds:804.1
原始文献类型	Journal article (JA)
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/87145
专题	iHuman研究所_PI研究组_水雯箐组生命科学与技术学院
通讯作者	Shui, Wenqing
作者单位	1.iHuman Institute, ShanghaiTech University, Shanghai; 201210, China 2.School of Life Science and Technology, ShanghaiTech University, Shanghai; 201210, China
第一作者单位	iHuman研究所
通讯作者单位	iHuman研究所; 生命科学与技术学院
第一作者的第一单位	iHuman研究所
推荐引用方式 GB/T 7714	Li, Shanshan,Shui, Wenqing. Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques[J]. CURRENT OPINION IN BIOTECHNOLOGY,2020,64:24-31.
APA	Li, Shanshan,&Shui, Wenqing.(2020).Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques.CURRENT OPINION IN BIOTECHNOLOGY,64,24-31.
MLA	Li, Shanshan,et al."Systematic mapping of protein–metabolite interactions with mass spectrometry-based techniques".CURRENT OPINION IN BIOTECHNOLOGY 64(2020):24-31.