Bioinspired Conical Micropattern Modulates Cell Behaviors

doi:10.1021/acsabm.8b00362

	Bioinspired Conical Micropattern Modulates Cell Behaviors
	Dai, Jing1,4,5 ; Kong, Na1 ; Lu, Yi 1; Yuan, Yangyang2 ; Wu, Qiong 3; Shi, Min 3; Zhang, Siyi 1; Wu, Yuzhe 1; Peng, Wenbo2 ; Huang, Pengyu2 ; Chen, Xuexin 3; Gong, Jinkang1 ; Yao, Yuan1
	2018
发表期刊	ACS APPLIED BIO MATERIALS (IF:4.6[JCR-2023],4.4[5-Year])
ISSN	25766422
卷号	1 期号:5 页码:1416-1423
发表状态	已发表
DOI	10.1021/acsabm.8b00362
摘要	The physical properties and topological cues of a micro/nanopattern affect both cell functional activity and tissue regeneration. In this study, we developed a bioinspired approach to fabricate a microconical pattern mimicking the wing structure of beetle Coleoptera. The bioinspired micropattern with multistructural hierarchy was first screened from eight representative insect families of coleopteran. Then, we fabricated a conical micropattern through a two-step nanoimprint lithography technology. We found that human adult fibroblast cells on the bioinspired micropattern substrate had a larger spread area and higher proliferation efficiency than those on flat polydimethylsiloxane. The physical properties and topological cues affect cell functional activity. Through in situ cell motility tracking, we found that conical pillars provided specific attachment points as a mechanotransduction foundation for cell attachment to spread. The holding pillar on the bioinspired surface facilitates the actin and vimentin filament assembly into mature straightened bundles in the cytoplasm. This bioinspired substrate is transparent, flexible, and easy to fabricate. Moreover, it provides a novel in situ platform to investigate cell behaviors. Copyright © 2018 American Chemical Society.
收录类别	EI ; ESCI
出版者	American Chemical Society
EI入藏号	20194007493610
EI主题词	Cell culture ; Fibroblasts ; Interfaces (materials) ; Lithography ; Nanoimprint lithography ; Physical properties ; Proteins ; Silicones ; Topology
EI分类号	Biomedical Engineering:461.1 ; Biology:461.9 ; Nanotechnology:761 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Combinatorial Mathematics, Includes Graph Theory, Set Theory:921.4 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Solid State Physics:933 ; Materials Science:951
原始文献类型	Journal article (JA)
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/86834
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_黄鹏羽组物质科学与技术学院_PI研究组_龚晋慷组物质科学与技术学院_博士生
通讯作者	Chen, Xuexin; Gong, Jinkang; Yao, Yuan
作者单位	1.School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong,Shanghai; 201210, China 2.School of Life Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong,Shanghai; 201210, China 3.Institute of Insect Science, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou; 310058, China 4.Shanghai Institute of Ceramics, Chinese Academy of Science, 1295 Dingxi Road, Changning,Shanghai; 200050, China 5.University of Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan,Beijing; 100049, China
第一作者单位	物质科学与技术学院
通讯作者单位	物质科学与技术学院
第一作者的第一单位	物质科学与技术学院
推荐引用方式 GB/T 7714	Dai, Jing,Kong, Na,Lu, Yi,et al. Bioinspired Conical Micropattern Modulates Cell Behaviors[J]. ACS APPLIED BIO MATERIALS,2018,1(5):1416-1423.
APA	Dai, Jing.,Kong, Na.,Lu, Yi.,Yuan, Yangyang.,Wu, Qiong.,...&Yao, Yuan.(2018).Bioinspired Conical Micropattern Modulates Cell Behaviors.ACS APPLIED BIO MATERIALS,1(5),1416-1423.
MLA	Dai, Jing,et al."Bioinspired Conical Micropattern Modulates Cell Behaviors".ACS APPLIED BIO MATERIALS 1.5(2018):1416-1423.