PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9

doi:10.1016/j.metabol.2019.02.005

	PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9
	Huang, Meiqin 1; Zhao, Zilong 1; Cao, Qianqian 1; You, Xue2 ; Wei, Siying 1; Zhao, Jingyu 1; Bai, Meijuan 1; Chen, Yan1,2
	2019-05
发表期刊	METABOLISM-CLINICAL AND EXPERIMENTAL (IF:10.8[JCR-2023],10.6[5-Year])
ISSN	0026-0495
卷号	94 页码:88-95
发表状态	已发表
DOI	10.1016/j.metabol.2019.02.005
摘要	Objective: Low-density lipoprotein cholesterol (LDL-C) is the hallmark of atherosclerotic cardiovascular diseases. The hepatic LDL receptor (LDLR) plays an important role in clearance of circulating LDL-C. PCSK9 facilitates degradation of LDLR in the lysosome and antagonizing PCSK9 has been successfully used in the clinic to reduce blood LDL-C level. Here we identify a new player that modulates LDLR interaction with PCSK9, thus controlling LDLR degradation and cholesterol homeostasis.
关键词	Low-density lipoprotein cholesterol LDLR PCSK9 Endosome Protein degradation
收录类别	SCI ; SCIE
语种	英语
资助项目	Chinese Academy of Sciences[XDA12010102] ; Chinese Academy of Sciences[QYZDJ-SSW-SMC008] ; Chinese Academy of Sciences[ZDRW-ZS-2016-8] ; Chinese Academy of Sciences[Y817X11141]
WOS研究方向	Endocrinology & Metabolism
WOS类目	Endocrinology & Metabolism
WOS记录号	WOS:000470306600010
出版者	W B SAUNDERS CO-ELSEVIER INC
WOS关键词	LOW-DENSITY-LIPOPROTEIN ; SUBTILISIN/KEXIN TYPE 9 ; HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA ; MONOCLONAL-ANTIBODY ; SERINE-PROTEASE ; PROPROTEIN ; RECEPTOR ; EFFICACY ; SAFETY ; TOLERABILITY
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/48973
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_陈雁组
通讯作者	Chen, Yan
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety, Shanghai Inst Nutr & Hlth,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Huang, Meiqin,Zhao, Zilong,Cao, Qianqian,et al. PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9[J]. METABOLISM-CLINICAL AND EXPERIMENTAL,2019,94:88-95.
APA	Huang, Meiqin.,Zhao, Zilong.,Cao, Qianqian.,You, Xue.,Wei, Siying.,...&Chen, Yan.(2019).PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9.METABOLISM-CLINICAL AND EXPERIMENTAL,94,88-95.
MLA	Huang, Meiqin,et al."PAQR3 modulates blood cholesterol level by facilitating interaction between LDLR and PCSK9".METABOLISM-CLINICAL AND EXPERIMENTAL 94(2019):88-95.