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| A canonical protein complex controls immune homeostasis and multipathogen resistance | |
Wu, Yue1,2; Xu, Weiying1,2; Zhao, Guoyan1,3  ; Lei, Ziyao1,2; Li, Kui4; Liu, Jiyun1; Huang, Shijia5; Wang, Junli6; Zhong, Xiangbin1; Yin, Xin1; Wang, Yuandong1,3; Zhang, Haochen1,3; He, Yang1; Ye, Zian4; Meng, Yonggang7,8; Chang, Xiaoyu7,8; Lin, Hui1; Wang, Xin1; Gao, Yuanyuan1; Chai, Jijie5; Parker, Jane E.6; Deng, Yiwen1,9; Zhang, Yu1; Gao, Mingjun4; He, Zuhua1
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| 2024-12-20 | |
| 发表期刊 | SCIENCE (IF:44.7[JCR-2023],50.3[5-Year]) |
| ISSN | 0036-8075 |
| EISSN | 1095-9203 |
| 卷号 | 386期号:6728 |
| 发表状态 | 已发表 |
| DOI | 10.1126/science.adr2138 |
| 摘要 | The calcium (Ca2+) sensor ROD1 (RESISTANCE OF RICE TO DISEASES1) is a master regulator of immunity in rice. By screening suppressors of rod1 mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in OsTIR (TIR-only protein), OsEDS1 (enhanced disease susceptibility 1), OsPAD4 (phytoalexin deficient 4), and OsADR1 (activated disease resistance 1) all abolish enhanced disease resistance of rod1 plants. OsTIR catalyzes the production of second messengers 2 '-(5 ''-phosphoribosyl)-5 '-adenosine monophosphate (pRib-AMP) and diphosphate (pRib-ADP), which trigger formation of an OsEDS1-OsPAD4-OsADR1 (EPA) immune complex. ROD1 interacts with OsTIR and inhibits its enzymatic activity, whereas mutation of ROD1 leads to constitutive activation of the EPA complex. Thus, we unveil an immune network that fine-tunes immune homeostasis and multipathogen resistance in rice. |
| URL | 查看原文 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[ |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:001386027500004 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 引用统计 | 正在获取...
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| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/471004 |
| 专题 | 生命科学与技术学院 生命科学与技术学院_博士生 |
| 共同第一作者 | Xu, Weiying; Zhao, Guoyan; Lei, Ziyao; Li, Kui; Liu, Jiyun |
| 通讯作者 | Deng, Yiwen; Zhang, Yu; Gao, Mingjun; He, Zuhua |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Fudan Univ, Sch Life Sci, Minist Educ,Key Lab Biodivers Sci & Ecol Engn, Natl Observat & Res Stn Wetland Ecosyst Yangtze Es, Shanghai 200433, Peoples R China 5.Westlake Univ, Inst Biol, Westlake Inst Adv Study, Sch Life Sci, Hangzhou 310024, Peoples R China 6.Max Planck Inst Breeding Res, Dept plant Microbe Interact, Carl-Von-Linne Weg 10, 50829 Cologne, Germany 7.Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China 8.Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Xinxiang 453007, Peoples R China 9.Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou 310058, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yue,Xu, Weiying,Zhao, Guoyan,et al. A canonical protein complex controls immune homeostasis and multipathogen resistance[J]. SCIENCE,2024,386(6728). |
| APA | Wu, Yue.,Xu, Weiying.,Zhao, Guoyan.,Lei, Ziyao.,Li, Kui.,...&He, Zuhua.(2024).A canonical protein complex controls immune homeostasis and multipathogen resistance.SCIENCE,386(6728). |
| MLA | Wu, Yue,et al."A canonical protein complex controls immune homeostasis and multipathogen resistance".SCIENCE 386.6728(2024). |
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