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High-resolution imaging atlas reveals context-dependent role of pancreatic sympathetic innervation in diabetic mice | |
2024-11-15 | |
状态 | 已发表 |
摘要 | Gaining a better understanding of how sympathetic nerves impact pancreatic function is helpful for understanding diabetes. However, there is still uncertainty and controversy surrounding the roles of sympathetic nerves within the pancreas. To address this, we utilize high-resolution imaging and advanced three-dimensional (3D) reconstruction techniques to study the patterns of sympathetic innervation and morphology in islets of adult WT and diabetic mice. Our data shows that more than ~30% α/β-cells are innervated by sympathetic nerves in both WT and diabetic mice. Also, sympathetic innervated α/β-cells are reduced in DIO mice, whereas sympathetic innervated β-cells are increased in db/db mice. Besides, in situ chemical pancreatic sympathetic denervation (cPSD) improves glucose tolerance in WT and db/db mice, but decreases in DIO mice. In situ cPSD also enhances insulin sensitivity in diabetic mice without affecting WT mice. Overall, our findings advance our comprehension of diabetes by highlighting the distinctive impact of pancreatic sympathetic innervation on glucose regulation. |
关键词 | High-resolution imaging sympathetic innervation α/β-cells chemical sympathetic denervation diabetes |
语种 | 英语 |
DOI | 10.1101/2024.11.14.623708 |
相关网址 | 查看原文 |
出处 | bioRxiv |
收录类别 | PPRN.PPRN |
WOS记录号 | PPRN:119216379 |
WOS类目 | Neurosciences |
资助项目 | Science and Technology Research Program of the Chongqing Municipal Education Commission[KJQN202300444] ; General project of the Natural Sciences Foundation of Chongqing[CSTB2022NSCQ-MSX0827] ; Science and Technology Commission of Shanghai Municipality["21JC1404900","21XD1422700","24ZR1451700"] ; National Natural Science Foundation of China["92357304","32330042","32425028","82070899"] |
文献类型 | 预印本 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/464729 |
专题 | 生命科学与技术学院 生命科学与技术学院_PI研究组_沈伟组 生命科学与技术学院_博士生 生命科学与技术学院_本科生 上海临床研究中心 |
通讯作者 | Li, Xi; Sun, Hongbin; Shen, Wei L |
作者单位 | 1.Chongqing Med Univ, Biol Sci Inst, Chongqing 400016, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.ShanghaiTech Univ, Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China 4.Tsinghua Univ, Inst Immunol, Tsinghua Med, Beijing 100084, Peoples R China 5.Tsinghua Univ, Sch Basic Med Sci, Tsinghua Med, Beijing 100084, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Qingqing,Chen, Yuxin,Ni, Xinyan,et al. High-resolution imaging atlas reveals context-dependent role of pancreatic sympathetic innervation in diabetic mice. 2024. |
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