High-resolution imaging atlas reveals context-dependent role of pancreatic sympathetic innervation in diabetic mice
2024-11-15
状态已发表
摘要Gaining a better understanding of how sympathetic nerves impact pancreatic function is helpful for understanding diabetes. However, there is still uncertainty and controversy surrounding the roles of sympathetic nerves within the pancreas. To address this, we utilize high-resolution imaging and advanced three-dimensional (3D) reconstruction techniques to study the patterns of sympathetic innervation and morphology in islets of adult WT and diabetic mice. Our data shows that more than ~30% α/β-cells are innervated by sympathetic nerves in both WT and diabetic mice. Also, sympathetic innervated α/β-cells are reduced in DIO mice, whereas sympathetic innervated β-cells are increased in db/db mice. Besides, in situ chemical pancreatic sympathetic denervation (cPSD) improves glucose tolerance in WT and db/db mice, but decreases in DIO mice. In situ cPSD also enhances insulin sensitivity in diabetic mice without affecting WT mice. Overall, our findings advance our comprehension of diabetes by highlighting the distinctive impact of pancreatic sympathetic innervation on glucose regulation.
关键词High-resolution imaging sympathetic innervation α/β-cells chemical sympathetic denervation diabetes
语种英语
DOI10.1101/2024.11.14.623708
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出处bioRxiv
收录类别PPRN.PPRN
WOS记录号PPRN:119216379
WOS类目Neurosciences
资助项目Science and Technology Research Program of the Chongqing Municipal Education Commission[KJQN202300444] ; General project of the Natural Sciences Foundation of Chongqing[CSTB2022NSCQ-MSX0827] ; Science and Technology Commission of Shanghai Municipality["21JC1404900","21XD1422700","24ZR1451700"] ; National Natural Science Foundation of China["92357304","32330042","32425028","82070899"]
文献类型预印本
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/464729
专题生命科学与技术学院
生命科学与技术学院_PI研究组_沈伟组
生命科学与技术学院_博士生
生命科学与技术学院_本科生
上海临床研究中心
通讯作者Li, Xi; Sun, Hongbin; Shen, Wei L
作者单位
1.Chongqing Med Univ, Biol Sci Inst, Chongqing 400016, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
3.ShanghaiTech Univ, Shanghai Clin Res & Trial Ctr, Shanghai 201210, Peoples R China
4.Tsinghua Univ, Inst Immunol, Tsinghua Med, Beijing 100084, Peoples R China
5.Tsinghua Univ, Sch Basic Med Sci, Tsinghua Med, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714
Xu, Qingqing,Chen, Yuxin,Ni, Xinyan,et al. High-resolution imaging atlas reveals context-dependent role of pancreatic sympathetic innervation in diabetic mice. 2024.
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