PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells

doi:10.18632/oncotarget.9807

	PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells
	Huang, Wenqiang 1; Guo, Weiwei 1; You, Xue1,2 ; Pan, Yi 1; Dong, Zhenyang 3; Jia, Gaozhen 3; Yang, Chenghua 1,4; Chen, Yan1,2
	2017-08
发表期刊	ONCOTARGET
ISSN	1949-2553
卷号	8 期号:33 页码:53948-53958
发表状态	已发表
DOI	10.18632/oncotarget.9807
摘要	As a newly discovered tumor suppressor, the potential function of PAQR3 in human prostate cancer has not been demonstrated. In this study, we report that PAQR3 is able to inhibit the growth and migration of human prostate cancer cells both in vitro and in vivo. Overexpression of PAQR3 inhibits the proliferation of PC3 and DU145 cells by both MTT and colony formation assays. Consistently, knockdown of PAQR3 enhances the proliferation of these cells. In wound-healing and transwell assays, overexpression of PAQR3 reduces the migration of PC3 and DU145 cells, while PAQR3 knockdown increases it. In a tumor xenograft model, overexpression of PAQR3 suppresses tumor growth of PC3 cells in vivo, while PAQR3 knockdown promotes the tumor growth. PAQR3 is also able to inhibit serum-induced phosphorylation of AKT and ERK in both PC3 and DU145 cells. In addition, PAQR3 suppresses the expression of epithelial-mesenchymal transition (EMT) markers in PC3 cells. Collectively, these data indicate that PAQR3 has a tumor suppressive activity in human prostate cancer cells and may stand out as a potential therapeutic target for prostate cancers.
关键词	human prostate cancer PAQR3 cell proliferation cell migration tumor xenograft
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of China[2012CB524900]
WOS研究方向	Oncology ; Cell Biology
WOS类目	Oncology ; Cell Biology
WOS记录号	WOS:000407826100005
出版者	IMPACT JOURNALS LLC
WOS关键词	TUMOR-SUPPRESSOR ; CARCINOMA ; RKTG ; CHEMOTHERAPY ; RECEPTOR ; PLAYS
原始文献类型	Article
通讯作者	Yang, Chenghua ; Chen, Yan
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/4527
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_陈雁组生命科学与技术学院_博士生
通讯作者	Yang, Chenghua; Chen, Yan
作者单位	1.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China 4.Second Mil Med Univ, Shanghai Changhai Hosp, Joint Ctr Translat Res Chron Dis, Shanghai 2000433, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Huang, Wenqiang,Guo, Weiwei,You, Xue,et al. PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells[J]. ONCOTARGET,2017,8(33):53948-53958.
APA	Huang, Wenqiang.,Guo, Weiwei.,You, Xue.,Pan, Yi.,Dong, Zhenyang.,...&Chen, Yan.(2017).PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells.ONCOTARGET,8(33),53948-53958.
MLA	Huang, Wenqiang,et al."PAQR3 suppresses the proliferation, migration and tumorigenicity of human prostate cancer cells".ONCOTARGET 8.33(2017):53948-53958.