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ShanghaiTech University Knowledge Management System
Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice | |
2024-11-01 | |
发表期刊 | NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year]) |
ISSN | 2041-1723 |
EISSN | 2041-1723 |
卷号 | 15期号:1 |
发表状态 | 已发表 |
DOI | 10.1038/s41467-024-53814-0 |
摘要 | ["Oral tolerance is essential for intestinal homeostasis and systemic immune function. However, our understanding of how oral tolerance is maintained is inadequate. Here we report that food-derived nucleic acids promote oral tolerance through innate sensing pathways. We find that dietary nucleic acids, but not microbiota, expand the natural intraepithelial lymphocyte (IEL) pool, specifically in the small intestine. TGF-beta 1, produced by natural IELs, then promotes activation of gut CD103+ dendritic cells to support the induction of antigen-specific Treg cells in a mouse model of OVA-induced oral tolerance. Mechanistically, MAVS and STING are redundantly required for sensing dietary RNAs and DNAs to activate downstream TBK1 signalling to induce IL-15 production, which results in the accumulation of natural IELs. Thus, our study demonstrates a key role of food-triggered innate sensing pathways in the maintenance of natural IELs and oral tolerance.","Oral tolerance is an important feature of gut immune homeostasis but how it is maintained is not fully known. Here authors show in a mouse model that dietary nucleic acids activate the MAVS and STING pathways, which leads to an increased abundance of natural intraepithelial lymphocytes, producing soluble factors that maintain tolerance."] |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | the National Key R&D Program of China (2020YFA0509100 and 2018YFA0507402), the National Natural Science Foundation of China (91842306, 81830018, and 32030039)[ |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001346598500012 |
出版者 | NATURE PORTFOLIO |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/446031 |
专题 | 生命科学与技术学院 生命科学与技术学院_特聘教授组_钱友存组 生命科学与技术学院_博士生 |
通讯作者 | Qian, Youcun |
作者单位 | 1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Nutr & Hlth, CAS Key Lab Tissue Microenvironm & Tumor, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China 3.Guangzhou Med Univ, State Key Lab Resp Dis, Affiliated Canc Hosp & Inst, Guangzhou 510180, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Yang, Tao,Li, Tian,Xing, Yingying,et al. Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice[J]. NATURE COMMUNICATIONS,2024,15(1). |
APA | Yang, Tao.,Li, Tian.,Xing, Yingying.,Cao, Mengtao.,Zhang, Mingxiang.,...&Qian, Youcun.(2024).Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice.NATURE COMMUNICATIONS,15(1). |
MLA | Yang, Tao,et al."Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice".NATURE COMMUNICATIONS 15.1(2024). |
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