Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives

doi:10.3389/fimmu.2024.1448952

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	Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives
	Fan, Mengjie 1; Fan, Xiaoyao 1; Lai, Yangfan 1; Chen, Jin 1; Peng, Yifan2 ; Peng, Yao2 ; Xiang, Leihong 1; Ma, Ying 1
	2024-09-05
发表期刊	FRONTIERS IN IMMUNOLOGY (IF:5.7[JCR-2023],6.8[5-Year])
ISSN	1664-3224
卷号	15
发表状态	已发表
DOI	10.3389/fimmu.2024.1448952
摘要	Protease-activated receptor-2 (PAR2) is a class-A G protein-coupled receptor (GPCR) activated by serine proteases and is expressed by multiple tissues, including the skin. PAR2 is involved in the skin inflammatory response, promoting Th2 inflammation, delaying skin barrier repair, and affecting the differentiation of keratinocytes. It also participates in the transmission of itch and pain sensations in the skin. Increasing evidence indicates that PAR2 plays an important role in the pathogenesis of inflammatory skin diseases such as acne vulgaris, rosacea, psoriasis, and atopic dermatitis. Additional focus will be placed on potential targeted therapies based on PAR2. The Goal of this review is to outline the emerging effects of PAR2 activation in inflammatory skin disease and highlight the promise of PAR2 modulators.
关键词	Protease-Activated Receptor 2 inflammatory skin disease serine protease skin barrier acne vulgaris atopic dermatitis targeted therapy
URL	查看原文
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[
WOS研究方向	Immunology
WOS类目	Immunology
WOS记录号	WOS:001322120900001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/433522
专题	iHuman研究所 iHuman研究所_特聘教授组_Raymond Stevens组生命科学与技术学院_博士生
通讯作者	Ma, Ying
作者单位	1.Fudan Univ, Dept Dermatol, Huashan Hosp, Shanghai, Peoples R China 2.ShanghaiTech Univ, iHuman Inst, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Fan, Mengjie,Fan, Xiaoyao,Lai, Yangfan,et al. Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives[J]. FRONTIERS IN IMMUNOLOGY,2024,15.
APA	Fan, Mengjie.,Fan, Xiaoyao.,Lai, Yangfan.,Chen, Jin.,Peng, Yifan.,...&Ma, Ying.(2024).Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives.FRONTIERS IN IMMUNOLOGY,15.
MLA	Fan, Mengjie,et al."Protease-Activated Receptor 2 in inflammatory skin disease: current evidence and future perspectives".FRONTIERS IN IMMUNOLOGY 15(2024).