Spatial dissociation between recognition and navigation in the primate hippocampus

doi:10.1126/sciadv.ado7392

	Spatial dissociation between recognition and navigation in the primate hippocampus
	Xu, Xiao (许霄)1,2,3 ; Du, Kechen (杜可晨)1,4; Mao, Dun (毛盾)1,4
	2024-09
发表期刊	SCIENCE ADVANCES (IF:11.7[JCR-2023],13.7[5-Year])
ISSN	2375-2548
EISSN	2375-2548
卷号	10 期号:38
发表状态	已发表
DOI	10.1126/sciadv.ado7392
摘要	The primate hippocampus, crucial for both episodic memory and spatial navigation, remains an enigma regarding whether these functions share the same neural substrates. We investigated how identical hippocampal neurons in macaque monkeys dynamically shifted their representations between tasks. In a recognition memory task, a notable fraction of hippocampal neurons showed that rate modulation strongly correlated with recognition performance. During free navigation in an open arena, spatial view, rather than position, predominantly influenced the spatial selectivity of hippocampal neurons. Neurons selective for recognition memory displayed minimal spatial tuning, while spatially tuned neurons exhibited limited memory-related activity. These neural correlates of recognition memory and space were more pronounced in the anterior and posterior portions of the hippocampus, respectively. These opposing gradients extended further into the anterior and posterior neocortices. Overall, our findings suggest the presence of orthogonal long-axis gradients between recognition memory and spatial navigation in the hippocampal-neocortical networks of macaque monkeys. Copyright © 2024 The Authors, some rights reserved.
关键词	Brain Macroinvertebrates Neurons Orthogonal functions Episodic memory Hippocampal neurons Limited memory Macaque monkeys Neural correlate Neural substrates Performance Recognition memory Spatial navigation Spatial selectivity
URL	查看原文
收录类别	EI ; SCI
语种	英语
资助项目	National Science and Technology Innovation 2030 Major Program[2022ZD0205000] ; National Natural Science Foundation of China[32371076] ; Lingang Lab[LG202105-01-08]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001328515500023
出版者	American Association for the Advancement of Science
EI入藏号	20243917099398
EI主题词	Mammals
EI分类号	101.1 ; 103 ; 1201 ; 821 Agricultural Equipment and Methods ; Vegetation and Pest Control
原始文献类型	Journal article (JA)
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/421475
专题	生命科学与技术学院生命科学与技术学院_博士生
共同第一作者	Du, Kechen (杜可晨)
通讯作者	Mao, Dun (毛盾)
作者单位	1.Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Key Laboratory of Brain Cognition and Brain-inspired Intelligence, Chinese Academy of Sciences 2.School of Life Science and Technology, ShanghaiTech University 3.Lingang laboratory 4.University of Chinese Academy of Sciences
第一作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Xu, Xiao ,Du, Kechen ,Mao, Dun . Spatial dissociation between recognition and navigation in the primate hippocampus[J]. SCIENCE ADVANCES,2024,10(38).
APA	Xu, Xiao ,Du, Kechen ,&Mao, Dun .(2024).Spatial dissociation between recognition and navigation in the primate hippocampus.SCIENCE ADVANCES,10(38).
MLA	Xu, Xiao ,et al."Spatial dissociation between recognition and navigation in the primate hippocampus".SCIENCE ADVANCES 10.38(2024).