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An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis | |
Liu, Junzhong1; Feng, Lili1,2,3; Gu, Xueting1,2; Deng, Xian4,5; Qiu, Qi2,4,5; Li, Qun1; Zhang, Yingying1; Wang, Muyang1,6; Deng, Yiwen1; Wang, Ertao1 | |
2019-05 | |
发表期刊 | CELL RESEARCH |
ISSN | 1001-0602 |
卷号 | 29期号:5页码:379-390 |
发表状态 | 已发表 |
DOI | 10.1038/s41422-019-0145-8 |
摘要 | Global warming has profound effects on plant growth and fitness. Plants have evolved sophisticated epigenetic machinery to respond quickly to heat, and exhibit transgenerational memory of the heat-induced release of post-transcriptional gene silencing (PTGS). However, how thermomemory is transmitted to progeny and the physiological relevance are elusive. Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2) directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6 (REF6), which in turn derepresses HSFA2. REF6 and HSFA2 establish a heritable feedback loop, and activate an E3 ubiquitin ligase, SUPPRESSOR OF GENE SILENCING 3 (SGS3)-INTERACTING PROTEIN 1 (SGIP1). SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA (tasiRNA). The REF6-HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5 (HTT5), which drives early flowering but attenuates immunity. Thus, heat induces transmitted phenotypes via a coordinated epigenetic network involving histone demethylases, transcription factors, and tasiRNAs, ensuring reproductive success and transgenerational stress adaptation. |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | Youth Innovation Promotion Association of CAS[2018131] |
WOS研究方向 | Cell Biology |
WOS类目 | Cell Biology |
WOS记录号 | WOS:000466153400007 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | TRANSCRIPTION FACTOR ; EPIGENETIC REGULATION ; SIRNA BIOGENESIS ; DNA-SEQUENCE ; HEAT-STRESS ; MEMORY ; PATHWAYS ; PLANTS ; INHERITANCE ; MECHANISMS |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/40837 |
专题 | 生命科学与技术学院_硕士生 生命科学与技术学院_特聘教授组_何祖华组 |
通讯作者 | Cao, Xiaofeng; He, Zuhua |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Plant Physiol & Ecol, Natl Key Lab Plant Mol Genet CAS Ctr Excellence M, Shanghai 200032, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Chinese Acad Sci, State Key Lab Plant Genom, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Natl Ctr Plant Gene Res Beijing, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 6.Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Shanghai 201602, Peoples R China 7.Univ Potsdam, Inst Biochem & Biol, Potsdam, Germany 8.Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA 9.Chinese Acad Sci, Inst Genet & Dev Biol, CAS Ctr Excellence Mol Plant Sci, Beijing 100101, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Liu, Junzhong,Feng, Lili,Gu, Xueting,et al. An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis[J]. CELL RESEARCH,2019,29(5):379-390. |
APA | Liu, Junzhong.,Feng, Lili.,Gu, Xueting.,Deng, Xian.,Qiu, Qi.,...&He, Zuhua.(2019).An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis.CELL RESEARCH,29(5),379-390. |
MLA | Liu, Junzhong,et al."An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis".CELL RESEARCH 29.5(2019):379-390. |
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