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A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses | |
2024-06-15 | |
发表期刊 | NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year]) |
EISSN | 2041-1723 |
卷号 | 15期号:1 |
发表状态 | 已发表 |
DOI | 10.1038/s41467-024-49096-1 |
摘要 | ["The Omicron subvariants BQ.1.1, XBB.1.5, and XBB.1.16 of SARS-CoV-2 are known for their adeptness at evading immune responses. Here, we isolate a neutralizing antibody, 7F3, with the capacity to neutralize all tested SARS-CoV-2 variants, including BQ.1.1, XBB.1.5, and XBB.1.16. 7F3 targets the receptor-binding motif (RBM) region and exhibits broad binding to a panel of 37 RBD mutant proteins. We develop the IgG-like bispecific antibody G7-Fc using 7F3 and the cross-neutralizing antibody GW01. G7-Fc demonstrates robust neutralizing activity against all 28 tested SARS-CoV-2 variants and sarbecoviruses, providing potent prophylaxis and therapeutic efficacy against XBB.1 infection in both K18-ACE and BALB/c female mice. Cryo-EM structure analysis of the G7-Fc in complex with the Omicron XBB spike (S) trimer reveals a trimer-dimer conformation, with G7-Fc synergistically targeting two distinct RBD epitopes and blocking ACE2 binding. Comparative analysis of 7F3 and LY-CoV1404 epitopes highlights a distinct and highly conserved epitope in the RBM region bound by 7F3, facilitating neutralization of the immune-evasive Omicron variant XBB.1.16. G7-Fc holds promise as a potential prophylactic countermeasure against SARS-CoV-2, particularly against circulating and emerging variants.","In this study, the authors develop a potent bispecific antibody targeting two epitopes within the SARS-CoV-2 receptor binding domain and showing robust prophylactic and therapeutic efficacy against XBB.1 infection in mice."] |
URL | 查看原文 |
收录类别 | SCI |
语种 | 英语 |
资助项目 | R&D Program of Guangzhou Laboratory[SRPG22-003] ; Shanghai Municipal Science and Technology Major Project[ZD2021CY001] ; Ministry of Science and Technology of China[2021YFC2302500] ; National Natural Science Foundation of China["32370995","31771008","3197014"] ; National Key Research and Development Program of China[2023YFE0118200] ; Shanghai Municipal Education Commission[22SG16] ; National Science and Technology Major Projects of China["2017ZX10202102","2018ZX10301403"] ; Shanghai Municipal Commission of Health and Family Planning[2018BR08] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:001249166000003 |
出版者 | NATURE PORTFOLIO |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/395893 |
专题 | 免疫化学研究所 生命科学与技术学院_博士生 免疫化学研究所_特聘教授组_赵金存组 |
通讯作者 | Zhao, Jincun; Wu, Fan; Huang, Jinghe; Sun, Lei |
作者单位 | 1.Fudan Univ, Shanghai Peoples Hosp 5, Shanghai Inst Infect Dis & Biosecur, Inst Biomed Sci,Sch Basic Med Sci, Shanghai, Peoples R China 2.Fudan Univ, Shanghai Frontiers Sci Ctr Pathogen Microorganisms, Sch Basic Med Sci, Shanghai, Peoples R China 3.Shanghai Jiao Tong Univ, Affiliated Renji Hosp, Shanghai Immune Therapy Inst, Sch Med, Shanghai, Peoples R China 4.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth, State Key Lab Resp Dis,Natl Clin Res Ctr Resp Dis, Guangzhou 510120, Peoples R China 5.ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Sch Life Sci & Technol, Shanghai, Peoples R China |
通讯作者单位 | 免疫化学研究所 |
推荐引用方式 GB/T 7714 | Wang, Yingdan,Hao, Aihua,Ji, Ping,et al. A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses[J]. NATURE COMMUNICATIONS,2024,15(1). |
APA | Wang, Yingdan.,Hao, Aihua.,Ji, Ping.,Ma, Yunping.,Zhang, Zhaoyong.,...&Sun, Lei.(2024).A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses.NATURE COMMUNICATIONS,15(1). |
MLA | Wang, Yingdan,et al."A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses".NATURE COMMUNICATIONS 15.1(2024). |
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