Ubiquitin Ligase MARCH5 Regulates the Formation of Mitochondria Derived Pre-peroxisomes

doi:10.1101/2023.10.26.564169

	Ubiquitin Ligase MARCH5 Regulates the Formation of Mitochondria Derived Pre-peroxisomes
	Zheng, Jun 1; Cao, Zhihe1 ; Wang, Jinhui 2; Guo, Yusong 2; Zhuang, Min1
	2023-10-26
状态	已发表
摘要	Peroxisome biogenesis involves two pathways: growth and division from pre-existing mature peroxisomes and de novo biogenesis from the endoplasmic reticulum, with a contribution from mitochondria, particularly in peroxisome deficient cells. However, the key components that regulate peroxisome de novo biogenesis are largely unknown. Dual organelle localized ubiquitin ligase MARCH5 functions on peroxisomes to regulate pexophagy. Here, we show that mitochondria localized MARCH5 is essential for the formation of vesicles in the de novo biogenesis of peroxisomes from mitochondria. Loss of MARCH5 specifically impedes the budding of PEX3-containing vesicles from mitochondria, thereby blocking the formation of pre-peroxisomes. Overall, our study highlights a novel function of MARCH5 for mitochondria derived pre-peroxisomes, emphasizing MARCH5 as one key regulator to maintain peroxisome homeostasis.
语种	英语
DOI	10.1101/2023.10.26.564169
相关网址	查看原文
出处	bioRxiv
收录类别	PPRN.PPRN
WOS记录号	PPRN:85784915
WOS类目	Cell Biology
文献类型	预印本
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/381341
专题	生命科学与技术学院生命科学与技术学院_PI研究组_庄敏组生命科学与技术学院_博士生
通讯作者	Zhuang, Min
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Jun,Cao, Zhihe,Wang, Jinhui,et al. Ubiquitin Ligase MARCH5 Regulates the Formation of Mitochondria Derived Pre-peroxisomes. 2023.