Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging

doi:10.1016/j.neuron.2024.02.006.

	Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging
	Hankui Cheng 1,2,6; Du Chen 1,2,6; Xiao Li 1,2,6; Umar Al-Sheikh 1,2; Duo Duan 1,2; Yuedan Fan 1,2; Linhui Zhu 1,2; Wanxin Zeng3 ; Zhitao Hu 4; Xiajing Tong3 ; Guohua Zhao 1; Yongming Zhang 5; Wenjuan Zou 1,2; Shumin Duan 2; Lijun Kang 1,2,7
	2024-05-01
发表期刊	NEURON
ISSN	112, 1–14,
EISSN	1097-4199
卷号	112 期号:9
发表状态	已发表
DOI	10.1016/j.neuron.2024.02.006.
摘要	Phasic (fast) and tonic (sustained) inhibition of g-aminobutyric acid (GABA) are fundamental for regulating day-to-day activities, neuronal excitability, and plasticity. However, the mechanisms and physiological functions of glial GABA transductions remain poorly understood. Here, we report that the AMsh glia in Caenorhabditis elegans exhibit both phasic and tonic GABAergic signaling, which distinctively regulate olfactory adaptation and neuronal aging. Through genetic screening, we find that GABA permeates through bestrophin-9/-13/-14 anion channels from AMsh glia, which primarily activate the metabolic GABA B receptor GBB-1 in the neighboring ASH sensory neurons. This tonic action of glial GABA regulates the age -associated changes of ASH neurons and olfactory responses via a conserved signaling pathway, inducing neuroprotection. In addition, the calcium -evoked, vesicular glial GABA release acts upon the ionotropic GABA A receptor LGC-38 in ASH neurons to regulate olfactory adaptation. These findings underscore the fundamental significance of glial GABA in maintaining healthy aging and neuronal stability.
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收录类别	SCI
语种	英语
资助项目	National Foundation of Natural Science of China["32271017","31771113","31471023","31800878"] ; Zhejiang Provincial Natural Science Foundation[LZ22C090001] ; Research Center of Prevention and Treatment of Senescence Syndrome of School of Medicine Zhejiang University[2022020001] ; Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences[2023-PT310-01] ; National Institutes of Health - Office of Research Infrastructure Programs[P40 OD010440] ; STI2030 Major Projects[2021ZD0203303]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:001238818600002
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/357309
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_童夏静组
共同第一作者	Du Chen; Xiao Li
通讯作者	Lijun Kang
作者单位	1.Department of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu 322000, China 2.MOE Frontier Science Center for Brain Science and Brain machine Integration, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310053, China 3.School of Life Science and Technology, ShanghaiTech University, Shanghai, China 4.Department of Neuroscience, City University of Hong Kong, Kowloon, China 5.Department of Ophthalmology of the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China 6.MOE Frontier Science Center for Brain Science and Brain machine Integration, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310053, China. 7.Department of Neurology of the Fourth Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Yiwu 322000, China; MOE Frontier Science Center for Brain Science and Brain machine Integration, NHC and CAMS Key Laboratory of Medical Neurobiology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310053, China. Electronic address: kanglijun@zju.edu.cn.
推荐引用方式 GB/T 7714	Hankui Cheng,Du Chen,Xiao Li,et al. Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging[J]. NEURON,2024,112(9).
APA	Hankui Cheng.,Du Chen.,Xiao Li.,Umar Al-Sheikh.,Duo Duan.,...&Lijun Kang.(2024).Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging.NEURON,112(9).
MLA	Hankui Cheng,et al."Phasic/tonic glial GABA differentially transduce for olfactory adaptation and neuronal aging".NEURON 112.9(2024).