Oxytocin neurons mediate stress-induced social memory impairment

doi:10.1016/j.cub.2023.11.037

	Oxytocin neurons mediate stress-induced social memory impairment
	Zhan, Shulu1,2,3,4 ; Qi, Zhenhua 6; Cai, Fang1 ; Gao, Zilong 5; Xie, Jingdun 6; Hu, Ji1,2
	2023-12
发表期刊	CURRENT BIOLOGY (IF:8.1[JCR-2023],9.8[5-Year])
ISSN	0960-9822
EISSN	1879-0445
卷号	34 期号:1
发表状态	已发表
DOI	10.1016/j.cub.2023.11.037
摘要	Oxytocin has long been thought to play a substantial role in social behaviors, such as social attachment and parenting behavior. However, how oxytocin neurons respond to social and non-social stimuli is largely unknown, especially in high temporal resolution. Here, we recorded the in vivo real-time responses of oxytocin neurons in the paraventricular nucleus of the hypothalamus (PVN) in freely behaving mice. Our results revealed that oxytocin neurons were activated more significantly by stressors than social stimuli. The activation of oxytocin neurons was precisely correlated with struggling behavior during stress. Furthermore, we found that oxytocin mediated stress -induced social memory impairment. Our results reveal an important role of PVN oxytocin neurons in stress -induced social amnesia.
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收录类别	SCI
语种	英语
资助项目	STI2030-Major Projects[2021ZD0203900] ; National Natural Science Foundation of China["32330043","32192414","32200837","U22A20302"] ; Guangdong Basic and Applied Basic Research Foundation["2019B151502010","2022B1515120026"] ; Hefei National Research Center for Physical Sciences at the Microscale[KF2021006]
WOS研究方向	Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS类目	Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS记录号	WOS:001154619700001
出版者	CELL PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/347876
专题	生命科学与技术学院生命科学与技术学院_PI研究组_胡霁组生命科学与技术学院_博士生
通讯作者	Gao, Zilong; Xie, Jingdun; Hu, Ji
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, 393 Middle Huaxia Rd, Shanghai 201210, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Shanghai 200030, Peoples R China 3.Chinese Acad Sci, Inst Neurosci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Beijing CIBR, Chinese Inst Brain Res, Bldg 3,9,YIKE Rd,Zhongguancun Life Sci Pk, Beijing 102206, Peoples R China 6.Sun Yat Sen Univ, Canc Ctr, Dept Anesthesiol, State Key Lab Oncol South China, 651 Dongfeng East Rd, Guangzhou 510060, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Zhan, Shulu,Qi, Zhenhua,Cai, Fang,et al. Oxytocin neurons mediate stress-induced social memory impairment[J]. CURRENT BIOLOGY,2023,34(1).
APA	Zhan, Shulu,Qi, Zhenhua,Cai, Fang,Gao, Zilong,Xie, Jingdun,&Hu, Ji.(2023).Oxytocin neurons mediate stress-induced social memory impairment.CURRENT BIOLOGY,34(1).
MLA	Zhan, Shulu,et al."Oxytocin neurons mediate stress-induced social memory impairment".CURRENT BIOLOGY 34.1(2023).