Role of Olfactorily Responsive Neurons in the Right Dorsal Habenula-Ventral Interpeduncular Nucleus Pathway in Food-Seeking Behaviors of Larval Zebrafish

doi:10.1016/j.neuroscience.2019.01.057

	Role of Olfactorily Responsive Neurons in the Right Dorsal Habenula-Ventral Interpeduncular Nucleus Pathway in Food-Seeking Behaviors of Larval Zebrafish
	Chen, Wei-yu 1,2; Peng, Xiao-lan 1; Deng, Qiu-sui 1,2; Chen, Min-jia1,2,3 ; Du, Jiu-lin1,2,3 ; Zhang, Bai-bing 1,2
	2019-04-15
发表期刊	NEUROSCIENCE (IF:2.9[JCR-2023],3.0[5-Year])
ISSN	0306-4522
卷号	404 页码:259-267
发表状态	已发表
DOI	10.1016/j.neuroscience.2019.01.057
摘要	The habenula (Hb) plays important roles in emotion-related behaviors. Besides receiving inputs from the limbic system and basal ganglia, Hb also gets inputs from multiple sensory modalities. Sensory responses of Hb neurons in zebrafish are asymmetrical: the left dorsal Hb and right dorsal Hb (dHb) preferentially respond to visual and olfactory stimuli, respectively, implying different functions of the left and right dHb. While visual responses of the left dHb (L-dHb) have been implicated in light-preference behavior, the significance of olfactory responses of the right dHb (R-dHb) remains under-examined. It was reported that the R-dHb can gate innate attraction to a bile salt. However, considering a broad range of odors that R-dHb respond to, it is of interest to examine the role of R-dHb in other olfactory behaviors, especially food seeking, which is essential for animals' survival. Here, using in vivo whole-cell recording and calcium imaging, we first characterized food extract-evoked responses of Hb neurons. Responsive neurons preferentially locate in the R- but not L-dHb and exhibit either ON- (similar to 87%) or OFF-type responses (similar to 13%). Interestingly, this right-to-left asymmetry of olfactory responses converts into a ventral-to-dorsal pattern in the interpeduncular nucleus (IPN), a main downstream target of Hb. Combining behavior assay, we further found that genetic dysfunction or lesion of the R-dHb and its corresponding downstream ventral IPN (V-IPN) impair the food seeking-associated increase of swimming activity. Thus, our study indicates that the asymmetrical olfactory response in the R-dHb to V-IPN pathway plays an important role in food-seeking behavior of zebrafish larvae. (C) 2019 IBRO. Published by Elsevier Ltd. AU rights reserved.
关键词	Right dorsal habenula Interpeduncular nucleus Olfactory response Food-seeking behavior
收录类别	SCI ; SCIE
语种	英语
资助项目	Strategic Priority Research Program of Chinese Academy of Sciences[XDB32010200]
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000462917500022
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS关键词	LEFT-RIGHT ASYMMETRY ; LATERAL HABENULA ; BASAL GANGLIA ; ATTRACTION ; SIGNALS
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/34257
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_杜久林组
通讯作者	Du, Jiu-lin; Zhang, Bai-bing
作者单位	1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, State Key Lab Neurosci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, 19A Yu Quan Rd, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, 319 Yue Yang Rd, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Wei-yu,Peng, Xiao-lan,Deng, Qiu-sui,et al. Role of Olfactorily Responsive Neurons in the Right Dorsal Habenula-Ventral Interpeduncular Nucleus Pathway in Food-Seeking Behaviors of Larval Zebrafish[J]. NEUROSCIENCE,2019,404:259-267.
APA	Chen, Wei-yu,Peng, Xiao-lan,Deng, Qiu-sui,Chen, Min-jia,Du, Jiu-lin,&Zhang, Bai-bing.(2019).Role of Olfactorily Responsive Neurons in the Right Dorsal Habenula-Ventral Interpeduncular Nucleus Pathway in Food-Seeking Behaviors of Larval Zebrafish.NEUROSCIENCE,404,259-267.
MLA	Chen, Wei-yu,et al."Role of Olfactorily Responsive Neurons in the Right Dorsal Habenula-Ventral Interpeduncular Nucleus Pathway in Food-Seeking Behaviors of Larval Zebrafish".NEUROSCIENCE 404(2019):259-267.