Mitochondrial Transfer Ribonucleic Acid (mt-tRNA) Taurine Modification
2023-05-01
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS (IF:0.2[JCR-2023],0.3[5-Year])
ISSN1000-3282
卷号50期号:5
发表状态已发表
DOI10.16476/j.pibb.2023.0060
摘要

Transfer ribonucleic acid (tRNA) is the RNA molecule with the largest variety of post-transcriptional modifications. In particular its anticodon loop contains a large number of modifications. Mitochondria have a relatively independent protein synthesis system, mitochondrial tRNAs (mt-tRNAs) are all encoded by the mitochondrial genome. Studies have shown that 5-taurinomethyluridine modification (tau m5U) only exists at position 34 of mitochondrial tRNAs of higher eukaryotes, regulating the fidelity of codon and anticodon interaction and contributing to translation speed and fidelity. Human GTPBP3 and MTO1 mediate mitochondrial tau m5U modification, whose functional defects may cause mitochondrial encephalomyopathy. This review summarizes the biological properties of tau m5U modification and its modifying enzymes, providing a new insight into the mechanism of tau m5U modification and the pathogenesis of mitochondrial diseases caused by tau m5U modification defects.

关键词tRNA post-transcriptional modifications mitochondrial diseases biological functions
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收录类别SCI ; CSCD ; 北大核心
语种英语
资助项目National Key Research and Development Program of China[2021YFA1300800] ; National Natural Science Foundation of China[32271300]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:001003651500002
出版者CHINESE ACAD SCIENCES, INST BIOPHYSICS
来源库CNKI
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/321445
专题生命科学与技术学院
生命科学与技术学院_特聘教授组_王恩多组
生命科学与技术学院_博士生
通讯作者Wang, En-Duo; Zhou, Xiao-Long
作者单位
1.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100864, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
推荐引用方式
GB/T 7714
Peng, Gui-Xin,Wang, En-Duo,Zhou, Xiao-Long. Mitochondrial Transfer Ribonucleic Acid (mt-tRNA) Taurine Modification[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2023,50(5).
APA Peng, Gui-Xin,Wang, En-Duo,&Zhou, Xiao-Long.(2023).Mitochondrial Transfer Ribonucleic Acid (mt-tRNA) Taurine Modification.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,50(5).
MLA Peng, Gui-Xin,et al."Mitochondrial Transfer Ribonucleic Acid (mt-tRNA) Taurine Modification".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 50.5(2023).
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