A parabrachial-hypothalamic parallel circuit governs cold defense in mice

doi:doi.org/10.1038/s41467-023-40504-6

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	A parabrachial-hypothalamic parallel circuit governs cold defense in mice
	Yang, Wen Z.1,2; Xie, Hengchang1,2,3,4 ; Du, Xiaosa1,2 ; Zhou, Qian1,2,3,4 ; Xiao, Yan 1,2; Zhao, Zhengdong1,2 ; Jia, Xiaoning1,2 ; Xu, Jianhui 5; Zhang, Wen 3; Cai, Shuang 6; Li, Zhangjie1,2 ; Fu, Xin1,2 ; Hua, Rong 7; Cai, Junhao1,2 ; Chang, Shuang1,2 ; Sun, Jing1,2 ; Sun, Hongbin1,2 ; Xu, Qingqing 8; Ni, Xinyan1,2 ; Tu, Hongqing1,2 ; Zheng, Ruimao 9,10; Xu, Xiaohong 3; Wang, Hong 11,12; Fu, Yu 13; Wang, Liming 14; Li, Xi 8; Yang, Haitao1,2 ; Yao, Qiyuan 7; Yu, Tian 5,6; Shen, Qiwei 7; Shen, Wei L.1,2
	2023-08-15
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
ISSN	2041-1723
EISSN	2041-1723
卷号	14 期号:1
发表状态	已发表
DOI	doi.org/10.1038/s41467-023-40504-6
摘要	["Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the neural pathways responsible for cold defense regulation are still unclear. Here, we found that a pathway from the lateral parabrachial nucleus (LPB) to the dorsomedial hypothalamus (DMH), which runs parallel to the canonical LPB to preoptic area (POA) pathway, is also crucial for cold defense. Together, these pathways make an equivalent and cumulative contribution, forming a parallel circuit. Specifically, activation of the LPB & RARR; DMH pathway induced strong cold-defense responses, including increases in thermogenesis of brown adipose tissue (BAT), muscle shivering, heart rate, and locomotion. Further, we identified somatostatin neurons in the LPB that target DMH to promote BAT thermogenesis. Therefore, we reveal a parallel circuit governing cold defense in mice, which enables resilience to hypothermia and provides a scalable and robust network in heat production, reshaping our understanding of neural circuit regulation of homeostatic behaviors.","The neural mechanisms responsible for cold defense regulation are still unclear. Here, authors show parallel thermogenic pathways from the brain stem to the hypothalamus work together to enable resilience to cold temperature exposure and hypothermia."]
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收录类别	SCI
语种	英语
资助项目	ShanghaiTech University - National Key Research and Development Program of China[2019YFA0801900] ; National Nature Science Foundation of China[2019YFA0801900] ; Shanghai Science and Technology Committee of Shanghai City["32122039","32100825"] ; Shanghai Sailing Program["21JC1404900","21XD1422700"] ; Shanghai Municipal Education Commission[21YF1429800] ; Ministry of Science and Technology of China[20CG71] ; Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine at ShanghaiTech University[2017YFA0205903] ; Singapore National Medical Research Council[SKLGE-2303] ; Singapore National Research Foundation[MOH-000611-00] ; null[NRF-NRFI07-2021-0001]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001051523700017
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/319416
专题	免疫化学研究所生命科学与技术学院生命科学与技术学院_PI研究组_沈伟组生命科学与技术学院_博士生生命科学与技术学院_本科生免疫化学研究所_PI研究组_杨海涛组
通讯作者	Yu, Tian; Shen, Qiwei; Shen, Wei L.
作者单位	1.Shanghaitech Univ, Shanghai Inst Adv Immunochem Studies, Shanghai 201210, Peoples R China 2.Shanghaitech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Inst Neurosci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chengdu Med Coll, Thermoregulat & Inflammat Lab, Chengdu 610500, Sichuan, Peoples R China 6.Zunyi Med Univ, Guizhou Key Lab Anesthesia & Organ Protect, Zunyi 563006, Peoples R China 7.Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200433, Peoples R China 8.Chongqing Med Univ, Inst life Sci, Chongqing 400044, Peoples R China 9.Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100871, Peoples R China 10.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China 11.Chinese Acad Sci, Brain Cognit & Brain Dis Inst BCBDI, Shenzhen Inst Adv Technol, Beijing, Peoples R China 12.Shenzhen Hong Kong Inst Brain Sci Shenzhen Fundam, Shenzhen 518055, Peoples R China 13.ASTAR, Inst Mol & Cell Biol, Singapore 138667, Singapore 14.Inst Mol Physiol, Shenzhen Bay Lab, Shenzhen 518055, Peoples R China
第一作者单位	免疫化学研究所; 生命科学与技术学院
通讯作者单位	免疫化学研究所; 生命科学与技术学院
第一作者的第一单位	免疫化学研究所
推荐引用方式 GB/T 7714	Yang, Wen Z.,Xie, Hengchang,Du, Xiaosa,et al. A parabrachial-hypothalamic parallel circuit governs cold defense in mice[J]. NATURE COMMUNICATIONS,2023,14(1).
APA	Yang, Wen Z..,Xie, Hengchang.,Du, Xiaosa.,Zhou, Qian.,Xiao, Yan.,...&Shen, Wei L..(2023).A parabrachial-hypothalamic parallel circuit governs cold defense in mice.NATURE COMMUNICATIONS,14(1).
MLA	Yang, Wen Z.,et al."A parabrachial-hypothalamic parallel circuit governs cold defense in mice".NATURE COMMUNICATIONS 14.1(2023).