UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs

doi:10.1038/s41467-023-37137-0

	UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs
	Hao, Yue1,2,3 ; Liu, Haowen 4; Zeng, Xian-Ting1 ; Wang, Ya 5; Zeng, Wan-Xin1,2,3 ; Qian, Kang-Ying1,2,3 ; Li, Lei 4; Chi, Ming-Xuan1 ; Gao, Shangbang 5; Hu, Zhitao 4; Tong, Xia-Jing1
	2023-03-15
发表期刊	NATURE COMMUNICATIONS (IF:14.7[JCR-2023],16.1[5-Year])
EISSN	2041-1723
卷号	14 期号:1
发表状态	已发表
DOI	10.1038/s41467-023-37137-0
摘要	["Disturbed inhibitory synaptic transmission has functional impacts on neurodevelopmental and psychiatric disorders. An essential mechanism for modulating inhibitory synaptic transmission is alteration of the postsynaptic abundance of GABA(A)Rs, which are stabilized by postsynaptic scaffold proteins and recruited by presynaptic signals. However, how GABAergic neurons trigger signals to transsynaptically recruit GABA(A)Rs remains elusive. Here, we show that UNC-43/CaMKII functions at GABAergic neurons to recruit GABA(A)Rs and modulate inhibitory synaptic transmission at C. elegans neuromuscular junctions. We demonstrate that UNC-43 promotes presynaptic MADD-4B/Punctin secretion and NRX-1 alpha/Neurexin surface delivery. Together, MADD-4B and NRX-1 alpha recruit postsynaptic NLG-1/Neuroligin and stabilize GABA(A)Rs. Further, the excitation of GABAergic neurons potentiates the recruitment of NLG-1-stabilized-GABA(A)Rs, which depends on UNC-43, MADD-4B, and NRX-1. These data all support that UNC-43 triggers MADD-4B and NRX-1 alpha, which act as anterograde signals to recruit postsynaptic GABA(A)Rs. Thus, our findings elucidate a mechanism for pre- and postsynaptic communication and inhibitory synaptic transmission and plasticity.","The pre-and postsynaptic communication is critical for faithful synaptic transmission and induction of synaptic plasticity. Here, the authors found that CaMKII functions at GABAergic neurons to recruit GABA(A)Rs by triggering anterograde signals."]
URL	查看原文
收录类别	SCI
语种	英语
资助项目	STI2030-Major Projects[2021ZD0202500] ; National Natural Science Foundation of China[32170963] ; Science and Technology Commission of Shanghai Municipality["21ZR1481000","19JC1414100"] ; Major International (Regional) Joint Research Project[32020103007]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:001001692800002
出版者	NATURE PORTFOLIO
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/312319
专题	生命科学与技术学院生命科学与技术学院_PI研究组_童夏静组生命科学与技术学院_博士生生命科学与技术学院_本科生
通讯作者	Tong, Xia-Jing
作者单位	1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai 200031, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 4.Univ Queensland, Queensland Brain Inst, Clem Jones Ctr Ageing Dementia Res CJCADR, Brisbane, Qld 4072, Australia 5.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Hao, Yue,Liu, Haowen,Zeng, Xian-Ting,et al. UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs[J]. NATURE COMMUNICATIONS,2023,14(1).
APA	Hao, Yue.,Liu, Haowen.,Zeng, Xian-Ting.,Wang, Ya.,Zeng, Wan-Xin.,...&Tong, Xia-Jing.(2023).UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.NATURE COMMUNICATIONS,14(1).
MLA	Hao, Yue,et al."UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs".NATURE COMMUNICATIONS 14.1(2023).