VGLL4 plays a critical role in heart valve development and homeostasis

doi:10.1371/journal.pgen.1007977

	VGLL4 plays a critical role in heart valve development and homeostasis
	Yu, Wei 1; Ma, Xueyan 1; Xu, Jinjin 1; Heumueller, Andreas Wilhelm 1,2; Fei, Zhaoliang 1; Feng, Xue 1; Wang, Xiaodong3 ; Liu, Kuo 1; Li, Jinhui 1; Cui, Guizhong 1; Peng, Guangdun 1; Ji, Hongbin 1; Li, Jinsong 1; Jing, Naihe 1; Song, Hai 4,5; Lin, Zhiqiang 6; Zhao, Yun1,3 ; Wang, Zuoyun 1; Zhou, Bin1,3 ; Zhang, Lei1,3
	2019-02
发表期刊	PLOS GENETICS (IF:4.0[JCR-2023],4.9[5-Year])
ISSN	1553-7404
卷号	15 期号:2
发表状态	已发表
DOI	10.1371/journal.pgen.1007977
摘要	Heart valve disease is a major clinical problem worldwide. Cardiac valve development and homeostasis need to be precisely controlled. Hippo signaling is essential for organ development and tissue homeostasis, while its role in valve formation and morphology maintenance remains unknown. VGLL4 is a transcription cofactor in vertebrates and we found it was mainly expressed in valve interstitial cells at the post-EMT stage and was maintained till the adult stage. Tissue specific knockout of VGLL4 in different cell lineages revealed that only loss of VGLL4 in endothelial cell lineage led to valve malformation with expanded expression of YAP targets. We further semi-knockout YAP in VGLL4 ablated hearts, and found hyper proliferation of arterial valve interstitial cells was significantly constrained. These findings suggest that VGLL4 is important for valve development and manipulation of Hippo components would be a potential therapy for preventing the progression of congenital valve disease.
收录类别	SCI ; SCIE
语种	英语
资助项目	China Postdoctoral Science Foundation[BX201700264]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000459970100050
出版者	PUBLIC LIBRARY SCIENCE
WOS关键词	HIPPO PATHWAY ; CARDIAC-HYPERTROPHY ; GENE-EXPRESSION ; PROLIFERATION ; CELLS ; MICE
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30558
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_赵允组生命科学与技术学院_特聘教授组_张雷组生命科学与技术学院_特聘教授组_周斌组
通讯作者	Wang, Zuoyun; Zhou, Bin; Zhang, Lei
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol,Innovat Ctr Cel, State Key Lab Cell Biol,CAS Ctr Excellence Mol Ce, Shanghai, Peoples R China 2.Goethe Univ Hosp, Inst Cardiovasc Regenerat, Frankfurt, Germany 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 4.Zhejiang Univ, Inst Life Sci, Hangzhou, Zhejiang, Peoples R China 5.Zhejiang Univ, Innovat Ctr Cell Signaling Network, Hangzhou, Zhejiang, Peoples R China 6.Masonic Med Res Inst, Utica, NY USA
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yu, Wei,Ma, Xueyan,Xu, Jinjin,et al. VGLL4 plays a critical role in heart valve development and homeostasis[J]. PLOS GENETICS,2019,15(2).
APA	Yu, Wei.,Ma, Xueyan.,Xu, Jinjin.,Heumueller, Andreas Wilhelm.,Fei, Zhaoliang.,...&Zhang, Lei.(2019).VGLL4 plays a critical role in heart valve development and homeostasis.PLOS GENETICS,15(2).
MLA	Yu, Wei,et al."VGLL4 plays a critical role in heart valve development and homeostasis".PLOS GENETICS 15.2(2019).