Large-scale prediction of ADAR-mediated effective human A-to-I RNA editing

doi:10.1093/bib/bbx092

	Large-scale prediction of ADAR-mediated effective human A-to-I RNA editing
	Yao, Li 1,2; Wang, Heming3 ; Song, Yuanyuan 4; Dai, Zhen 5; Yu, Hao 6; Yin, Ming 7; Wang, Dongxu 6; Yang, Xin 8; Wang, Jinlin 7; Wang, Tiedong 6; Cao, Nan 9; Zhu, Jimin 1; Shen, Xizhong 1; Song, Guangqi 1; Zhao, Yicheng 10,11
	2019-01
发表期刊	BRIEFINGS IN BIOINFORMATICS (IF:6.8[JCR-2023],7.9[5-Year])
ISSN	1467-5463
卷号	20 期号:1 页码:102-109
发表状态	已发表
DOI	10.1093/bib/bbx092
摘要	Adenosine-to-inosine (A-to-I) editing by adenosine deaminase acting on the RNA (ADAR) proteins is one of the most frequent modifications during post- and co-transcription. To facilitate the assignment of biological functions to specific editing sites, we designed an automatic online platform to annotate A-to-I RNA editing sites in pre-mRNA splicing signals, microRNAs (miRNAs) and miRNA target untranslated regions (30 UTRs) from human (Homo sapiens) high-throughput sequencing data and predict their effects based on large-scale bioinformatic analysis. After analysing plenty of previously reported RNA editing events and human normal tissues RNA high-seq data, >60 000 potentially effective RNA editing events on functional genes were found. The RNA Editing Plus platform is available for free at https:// www. rnaeditplus. org/, and we believe our platform governing multiple optimized methods will improve further studies of A-to-I-induced editing posttranscriptional regulation.
关键词	RNA editing microRNA targeting alternative mRNA splicing gene mutation
收录类别	SCI ; SCIE
语种	英语
资助项目	Natural Science Foundation from Jiangsu Province[BK20160665]
WOS研究方向	Biochemistry & Molecular Biology ; Mathematical & Computational Biology
WOS类目	Biochemical Research Methods ; Mathematical & Computational Biology
WOS记录号	WOS:000456736200010
出版者	OXFORD UNIV PRESS
WOS关键词	ACCURATE IDENTIFICATION ; SITES ; DATABASE ; ALU
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30229
专题	生命科学与技术学院_硕士生
通讯作者	Song, Guangqi; Zhao, Yicheng
作者单位	1.Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China 2.Tsinghua Univ, Beijing, Peoples R China 3.ShanghaiTech Univ, Shanghai, Peoples R China 4.Chinese Acad Sci, Beijing, Peoples R China 5.Hannover Med Sch, Hannover, Germany 6.Jilin Univ, Changchun, Jilin, Peoples R China 7.Peking Univ, Beijing, Peoples R China 8.Southeast Univ, Nanjing, Jiangsu, Peoples R China 9.Peoples Bank China, Beijing, Peoples R China 10.Northeast Forestry Univ, Biol, Harbin, Heilongjiang, Peoples R China 11.Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA
推荐引用方式 GB/T 7714	Yao, Li,Wang, Heming,Song, Yuanyuan,et al. Large-scale prediction of ADAR-mediated effective human A-to-I RNA editing[J]. BRIEFINGS IN BIOINFORMATICS,2019,20(1):102-109.
APA	Yao, Li.,Wang, Heming.,Song, Yuanyuan.,Dai, Zhen.,Yu, Hao.,...&Zhao, Yicheng.(2019).Large-scale prediction of ADAR-mediated effective human A-to-I RNA editing.BRIEFINGS IN BIOINFORMATICS,20(1),102-109.
MLA	Yao, Li,et al."Large-scale prediction of ADAR-mediated effective human A-to-I RNA editing".BRIEFINGS IN BIOINFORMATICS 20.1(2019):102-109.