Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals
Zhao, Yu1; Liu, Changbo1; Liu, Zhixiang2; Luo, Wenhan3,4,5; Li, Lizhu1; Cai, Xue1; Liang, Dong1; Su, Yuanzhe1; Ding, He6; Wang, Qiang1; Yin, Lan7; Guan, Jisong4; Luo, Minmin2,8,9; Sheng, Xing1
2019-01
Source PublicationIEEE TRANSACTIONS ON ELECTRON DEVICES
ISSN0018-9383
Volume66Issue:1Pages:785-792
Status已发表
DOI10.1109/TED.2018.2882397
AbstractRecording and interrogating brain activities using optical methods have become emerging technologies in neuroscience. Traditional tools for optogenetic stimulation in the deep brain are mostly based on implantable fibers, imposing constraints on the animal movement. Recently developed microscale light-emitting diodes (micro-LEDs), which can be wirelessly operated, serve as injectable light sources that directly interact with neural systems. Here, we exploit a wirelessly controlled, implantable system for optogenetic studies in behaving animals. Thin-film indium gallium nitride (InGaN)based blue micro-LEDs transferred onto flexible probes are injected into the animal brain and optically activate channelrhodopsin-2 expressing neurons. A customized circuit module with a battery is employed to modulate the micro-LED, which is remotely controlled at a distance up to 50 m via 2.4-GHz radio frequency communications. The systems are implemented on freely moving mice, and demonstrate optogenetic modulation of locomotive behaviors in vivo. Moreover, independent and synchronous control of multiple animals is accomplished with the communication unit in the design circuit. The proposed system provides the potential for advanced optical neural interfaces and offers solutions to study complicated animal behaviors in neuroscience research.
KeywordImplantable devices micro-light-emitting diodes (LEDs) optogenetics wireless operation
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Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[61874064]
WOS Research AreaEngineering ; Physics
WOS SubjectEngineering, Electrical & Electronic ; Physics, Applied
WOS IDWOS:000454333500105
PublisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
WOS KeywordBRAIN ; DYNAMICS ; DEVICES
Original Document TypeArticle
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30014
Collection生命科学与技术学院_PI研究组_管吉松组
Corresponding AuthorSheng, Xing
Affiliation1.Tsinghua Univ, Beijing Natl Res Ctr Informat Sci & Technol, Dept Elect Engn, Beijing 100084, Peoples R China
2.Natl Inst Biol Sci, Beijing 102206, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
5.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
6.Beijing Inst Technol, Sch Opt & Photon, Beijing 100081, Peoples R China
7.Tsinghua Univ, Sch Mat Sci & Engn, Beijing 100084, Peoples R China
8.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
9.Chinese Inst Brain Res, Beijing 102206, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Yu,Liu, Changbo,Liu, Zhixiang,et al. Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals[J]. IEEE TRANSACTIONS ON ELECTRON DEVICES,2019,66(1):785-792.
APA Zhao, Yu.,Liu, Changbo.,Liu, Zhixiang.,Luo, Wenhan.,Li, Lizhu.,...&Sheng, Xing.(2019).Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals.IEEE TRANSACTIONS ON ELECTRON DEVICES,66(1),785-792.
MLA Zhao, Yu,et al."Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals".IEEE TRANSACTIONS ON ELECTRON DEVICES 66.1(2019):785-792.
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