Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals

doi:10.1109/TED.2018.2882397

	Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals
	Yu Zhao 1; Changbo Liu 1; Zhixiang Liu 2; Wenhan Luo 3; Lizhu Li 1; Xue Cai 1; Dong Liang 1; Yuanzhe Su 1; He Ding 4; Qiang Wang 1; Lan Yin 5; Jisong Guan6 ; Minmin Luo 2; Xing Sheng 1
	2019-01
发表期刊	IEEE TRANSACTIONS ON ELECTRON DEVICES
ISSN	0018-9383
卷号	66 期号:1 页码:785-792
发表状态	已发表
DOI	10.1109/TED.2018.2882397
摘要	Recording and interrogating brain activities using optical methods have become emerging technologies in neuroscience. Traditional tools for optogenetic stimulation in the deep brain are mostly based on implantable fibers, imposing constraints on the animal movement. Recently developed microscale light-emitting diodes (micro-LEDs), which can be wirelessly operated, serve as injectable light sources that directly interact with neural systems. Here, we exploit a wirelessly controlled, implantable system for optogenetic studies in behaving animals. Thin-film indium gallium nitride (InGaN)based blue micro-LEDs transferred onto flexible probes are injected into the animal brain and optically activate channelrhodopsin-2 expressing neurons. A customized circuit module with a battery is employed to modulate the micro-LED, which is remotely controlled at a distance up to 50 m via 2.4-GHz radio frequency communications. The systems are implemented on freely moving mice, and demonstrate optogenetic modulation of locomotive behaviors in vivo. Moreover, independent and synchronous control of multiple animals is accomplished with the communication unit in the design circuit. The proposed system provides the potential for advanced optical neural interfaces and offers solutions to study complicated animal behaviors in neuroscience research.
关键词	Implantable devices micro-light-emitting diodes (LEDs) optogenetics wireless operation
URL	查看原文
收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	National Natural Science Foundation of China[61874064]
WOS研究方向	Engineering ; Physics
WOS类目	Engineering, Electrical & Electronic ; Physics, Applied
WOS记录号	WOS:000454333500105
出版者	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
WOS关键词	BRAIN ; DYNAMICS ; DEVICES
原始文献类型	Article
来源库	IEEE
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/30014
专题	生命科学与技术学院_PI研究组_管吉松组
作者单位	1.Department of Electronic Engineering, Tsinghua University, Beijing, China 2.National Institute of Biological Sciences, Beijing, China 3.Peking-Tsinghua Center for Life Sciences, Beijing, China 4.School of Optics and Photonics, Beijing Institute of Technology, Beijing, China 5.School of Materials Science and Engineering, Tsinghua University, Beijing, China 6.School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China
推荐引用方式 GB/T 7714	Yu Zhao,Changbo Liu,Zhixiang Liu,et al. Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals[J]. IEEE TRANSACTIONS ON ELECTRON DEVICES,2019,66(1):785-792.
APA	Yu Zhao.,Changbo Liu.,Zhixiang Liu.,Wenhan Luo.,Lizhu Li.,...&Xing Sheng.(2019).Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals.IEEE TRANSACTIONS ON ELECTRON DEVICES,66(1),785-792.
MLA	Yu Zhao,et al."Wirelessly Operated, Implantable Optoelectronic Probes for Optogenetics in Freely Moving Animals".IEEE TRANSACTIONS ON ELECTRON DEVICES 66.1(2019):785-792.