Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries

doi:10.1021/acs.orglett.7b01297

	Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries
	Fan, Zhoulong 1,2,3; Li, Jie4 ; Lu, Heng4 ; Wang, Dong-Yu 1,2; Wang, Chao 5,6; Uchiyama, Masanobu 5,6; Zhang, Ao1,2,3,4
	2017-06-16
发表期刊	ORGANIC LETTERS (IF:4.9[JCR-2023],4.5[5-Year])
ISSN	1523-7060
卷号	19 期号:12 页码:3199-3202
发表状态	已发表
DOI	10.1021/acs.orglett.7b01297
摘要	A removable oxime-assisted meta-C-H nitration of arenes is reported. Mechanistic investigations and DFT calculations reveal a new monomeric octahedral ruthenium(II) complex is responsible for the meta-selective nitration. Dioxygen as a cooxidant is crucial for achieving high conversion and good yields. Moreover, the utility of the present reaction protocol is further showcased by the late-stage modification of the clinical CNS drugs Diazepam and Fluvoxamine.
收录类别	SCI ; IC ; CCR
语种	英语
资助项目	CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YKF-08] ; CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YZZ-06]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000403854300041
出版者	AMER CHEMICAL SOC
WOS关键词	AROMATIC-SUBSTITUTION REACTIONS ; ORTHO-METALATION STRATEGY ; FUNCTIONALIZATION ; BROMINATION ; ALKYLATION ; ACTIVATION ; REGIOSELECTIVITY ; SULFONATION ; LIGANDS ; BONDS
原始文献类型	Article
通讯作者	Zhang, Ao
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2912
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_张翱组生命科学与技术学院_博士生
通讯作者	Zhang, Ao
作者单位	1.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.ShanghaiTech Univ, Shanghai 201210, Peoples R China 5.Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan 6.RIKEN Ctr Sustainable Resource Sci & Elements Che, Adv Elements Chem Res Team, Wako, Saitama 3510198, Japan
通讯作者单位	上海科技大学
推荐引用方式 GB/T 7714	Fan, Zhoulong,Li, Jie,Lu, Heng,et al. Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries[J]. ORGANIC LETTERS,2017,19(12):3199-3202.
APA	Fan, Zhoulong.,Li, Jie.,Lu, Heng.,Wang, Dong-Yu.,Wang, Chao.,...&Zhang, Ao.(2017).Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries.ORGANIC LETTERS,19(12),3199-3202.
MLA	Fan, Zhoulong,et al."Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries".ORGANIC LETTERS 19.12(2017):3199-3202.