Phenyldivinylsulfonamides for the construction of antibody–drug conjugates with controlled four payloads

doi:10.1016/j.bioorg.2023.106463

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	Phenyldivinylsulfonamides for the construction of antibody–drug conjugates with controlled four payloads
	Ding Wei1,2,3 ; Yuecheng Jiang2,4 ; Yurong Mao2 ; Zili Xu2,4 ; Jiakang Chen2 ; Xiuxia Gao2 ; Jiusheng Li 1; Biao Jiang2 ; Hongli Chen2
	2023-03-12
发表期刊	BIOORGANIC CHEMISTRY (IF:4.5[JCR-2023],4.7[5-Year])
ISSN	0045-2068
EISSN	1090-2120
卷号	134
发表状态	已发表
DOI	10.1016/j.bioorg.2023.106463
摘要	Phenyldivinylsulfonamides emerged from a series of divinylsulfonamides, demonstrating their ability to effectively re-bridge disulfide bonds. This kind of linkers was attached to monomethyl auristatin E (MMAE) and further conjugated with a model antibody, trastuzumab. After optimization, the linker 20 can deliver stable and highly homogenous DAR (Drug-to-Antibody Ratio) four antibody–drug conjugates (ADCs). The method was also applicable for other IgG1 antibodies to obtain ADCs with controlled four payloads. Moreover, the MMAE-bearing ADC is potent, selective and efficacious against target cell lines.
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收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic
WOS记录号	WOS:000955491000001
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/290004
专题	免疫化学研究所物质科学与技术学院免疫化学研究所_特聘教授组_抗体化学实验室免疫化学研究所_公共科研平台_分析化学平台生命科学与技术学院_硕士生物质科学与技术学院_硕士生物质科学与技术学院_本科生物质科学与技术学院_博士生
共同第一作者	Yuecheng Jiang
通讯作者	Biao Jiang; Hongli Chen
作者单位	1.Green Chemical Engineering Technology Research Center, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, China 2.Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai, 201210, China 3.University of Chinese Academy of Sciences, 19A Yuquan Road, Shijingshan District, Beijing 100049, China 4.School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Pudong, Shanghai 201210, China
第一作者单位	免疫化学研究所
通讯作者单位	免疫化学研究所
推荐引用方式 GB/T 7714	Ding Wei,Yuecheng Jiang,Yurong Mao,et al. Phenyldivinylsulfonamides for the construction of antibody–drug conjugates with controlled four payloads[J]. BIOORGANIC CHEMISTRY,2023,134.
APA	Ding Wei.,Yuecheng Jiang.,Yurong Mao.,Zili Xu.,Jiakang Chen.,...&Hongli Chen.(2023).Phenyldivinylsulfonamides for the construction of antibody–drug conjugates with controlled four payloads.BIOORGANIC CHEMISTRY,134.
MLA	Ding Wei,et al."Phenyldivinylsulfonamides for the construction of antibody–drug conjugates with controlled four payloads".BIOORGANIC CHEMISTRY 134(2023).