The Diversity of Long Noncoding RNAs and Their Generation

doi:10.1016/j.tig.2017.05.004

	The Diversity of Long Noncoding RNAs and Their Generation
	Wu, Huang 1,2; Yang, Li2,3,4 ; Chen, Ling-Ling1,2,4
	2017-08
发表期刊	TRENDS IN GENETICS
ISSN	0168-9525
卷号	33 期号:8 页码:540-552
发表状态	已发表
DOI	10.1016/j.tig.2017.05.004
摘要	Long noncoding RNAs (lncRNAs) are emerging as potential key regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Several distinct classes of lncRNAs are transcribed from different DNA elements, including promoters, enhancers, and intergenic regions in eukaryotic genomes. Additionally, others are derived from long primary transcripts with noncanonical RNA processing pathways, generating new RNA species with unexpected formats. These lncRNAs can be processed by several mechanisms, including ribonuclease P (RNase P) cleavage to generate mature 30 ends, capping by small nucleolar RNA (snoRNA)-protein (snoRNP) complexes at their ends, or the formation of circular structures. Here we review current knowledge on lncRNAs and highlight the most recent discoveries of the underlying mechanisms related to their formation.
收录类别	SCI
语种	英语
资助项目	NSFC[91440202] ; NSFC[91540115]
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000405560000007
出版者	ELSEVIER SCIENCE LONDON
WOS关键词	PRADER-WILLI-SYNDROME ; CIRCULAR RNAS ; GENE-EXPRESSION ; MESSENGER-RNAS ; EXON CIRCULARIZATION ; TRIPLE-HELIX ; XENOPUS-TROPICALIS ; CIRCRNA BIOGENESIS ; TRANSCRIPTION ; PROMOTERS
原始文献类型	Review
通讯作者	Yang, Li ; Chen, Ling-Ling
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2877
专题	生命科学与技术学院_特聘教授组_杨力组生命科学与技术学院_特聘教授组_陈玲玲组
通讯作者	Yang, Li; Chen, Ling-Ling
作者单位	1.Chinese Acad Sci, State Key Lab Mol Biol, Shanghai Key Lab Mol Androl, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, 320 Yueyang Rd, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Computat Biol, CAS MPG Partner Inst Computat Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, 100 Haike Rd, Shanghai 201210, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wu, Huang,Yang, Li,Chen, Ling-Ling. The Diversity of Long Noncoding RNAs and Their Generation[J]. TRENDS IN GENETICS,2017,33(8):540-552.
APA	Wu, Huang,Yang, Li,&Chen, Ling-Ling.(2017).The Diversity of Long Noncoding RNAs and Their Generation.TRENDS IN GENETICS,33(8),540-552.
MLA	Wu, Huang,et al."The Diversity of Long Noncoding RNAs and Their Generation".TRENDS IN GENETICS 33.8(2017):540-552.