USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein

doi:10.1084/jem.20172026

	USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein
	Chen, Siyuan 1; Yun, Fenglin1,2 ; Yao, Yikun 1; Cao, Mengtao 1; Zhang, Yifan 1; Wang, Jingjing 1; Song, Xinyang 1; Qian, Youcun1,2
	2018-11
发表期刊	JOURNAL OF EXPERIMENTAL MEDICINE (IF:12.6[JCR-2023],14.1[5-Year])
ISSN	0022-1007
卷号	215 期号:11 页码:2850-2867
发表状态	已发表
DOI	10.1084/jem.20172026
摘要	Th2 immune response is critical for allergic asthma pathogenesis. Molecular mechanisms for regulating Th2 immunity are still not well understood. Here we report that the ubiquitin-specific protease USP38 is crucial for Th2-mediated allergic asthma. TCR stimulation up-regulated the USP38 level, and USP38 in turn mediated the protein stabilization of JunB, a transcription factor specific for Th2 development. Consequently, USP38 was specifically required for TCR-induced production of Th2 cytokines and Th2 development both in vitro and in vivo, and USP38-deficient mice were resistant to asthma pathogenesis induced by OVA or HDM. Mechanistically, USP38 directly associated with JunB, deubiquitinated Lys-48-linked poly-ubiquitination of JunB, and consequently blocked TCR-induced JunB turnover. USP38 represents the first identified deubiquitinase specifically for Th2 immunity and the associated asthma.
收录类别	SCI ; SCIE
语种	英语
资助项目	Strategic Priority Research Program of the Chinese Academy of Sciences[XDB19000000]
WOS研究方向	Immunology ; Research & Experimental Medicine
WOS类目	Immunology ; Medicine, Research & Experimental
WOS记录号	WOS:000449278300014
出版者	ROCKEFELLER UNIV PRESS
WOS关键词	HELPER-CELL DIFFERENTIATION ; E3 UBIQUITIN LIGASES ; NF-KAPPA-B ; DEUBIQUITINATING ENZYMES ; T-CELLS ; INFLAMMATORY RESPONSES ; T(H)2 DIFFERENTIATION ; ITCH ; ACTIVATION ; EXPRESSION
原始文献类型	Article
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/28683
专题	生命科学与技术学院_硕士生生命科学与技术学院_特聘教授组_钱友存组
通讯作者	Qian, Youcun
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci,Shanghai Inst Nutr & Hlth, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Key Lab Tissue Microenvironm & Tumor, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Siyuan,Yun, Fenglin,Yao, Yikun,et al. USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2018,215(11):2850-2867.
APA	Chen, Siyuan.,Yun, Fenglin.,Yao, Yikun.,Cao, Mengtao.,Zhang, Yifan.,...&Qian, Youcun.(2018).USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein.JOURNAL OF EXPERIMENTAL MEDICINE,215(11),2850-2867.
MLA	Chen, Siyuan,et al."USP38 critically promotes asthmatic pathogenesis by stabilizing JunB protein".JOURNAL OF EXPERIMENTAL MEDICINE 215.11(2018):2850-2867.