Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria

doi:10.1016/j.freeradbiomed.2017.04.363

	Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria
	Xiao, Mengqing1,2 ; Zhong, Huiqin 2,3; Xia, Lin 1,4; Tao, Yongzhen 1,4; Yin, Huiyong1,2,3,4
	2017-10
发表期刊	FREE RADICAL BIOLOGY AND MEDICINE (IF:7.1[JCR-2023],7.9[5-Year])
ISSN	0891-5849
EISSN	1873-4596
卷号	111 页码:316-327
发表状态	已发表
DOI	10.1016/j.freeradbiomed.2017.04.363
摘要	Mitochondrial lipids are essential for maintaining the integrity of mitochondrial membranes and the proper functions of mitochondria. As the "powerhouse" of a cell, mitochondria are also the major cellular source of reactive oxygen species (ROS). Oxidative stress occurs when the antioxidant system is overwhelmed by overproduction of ROS. Polyunsaturated fatty acids in mitochondrial membranes are primary targets for ROS attack, which may lead to lipid peroxidation (LPO) and generation of reactive lipids, such as 4-hydroxynonenal. When mitochondrial lipids are oxidized, the integrity and function of mitochondria may be compromised and this may eventually lead to mitochondrial dysfunction, which has been associated with many human diseases including cancer, cardiovascular diseases, diabetes, and neurodegenerative diseases. How mitochondrial lipids are oxidized and the underlying molecular mechanisms and pathophysiological consequences associated with mitochondrial LPO remain poorly defined. Oxidation of the mitochondria-specific phospholipid cardiolipin and generation of bioactive lipids through mitochondrial LPO has been increasingly recognized as an important event orchestrating apoptosis, metabolic reprogramming of energy production, mitophagy, and immune responses. In this review, we focus on the current understanding of how mitochondrial LPO and generation of bioactive lipid mediators in mitochondria are involved in the modulation of mitochondrial functions in the context of relevant human diseases associated with oxidative stress.
关键词	Lipid peroxidation 4-hydroxy-2-nonenal (4-HNE) Mitochondrial dysfunction Neurodegenerative diseases Cancer Diabetes Cardiovascular disease
收录类别	SCI
语种	英语
资助项目	Chinese National Natural Science Foundation of China[31170809] ; Chinese National Natural Science Foundation of China[31401015] ; Chinese National Natural Science Foundation of China[21402221] ; Chinese National Natural Science Foundation of China[31470831] ; Chinese National Natural Science Foundation of China[91439103] ; Chinese National Natural Science Foundation of China[91539127]
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS类目	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
WOS记录号	WOS:000406049900028
出版者	ELSEVIER SCIENCE INC
WOS关键词	FATTY-ACID OXIDATION ; TRAUMATIC BRAIN-INJURY ; PHOSPHOLIPASE A(2)GAMMA IPLA(2)GAMMA ; ALZHEIMERS-DISEASE ; PARKINSONS-DISEASE ; INSULIN-RESISTANCE ; REDOX PROTEOMICS ; HEART-FAILURE ; PERMEABILITY TRANSITION ; DILATED CARDIOMYOPATHY
原始文献类型	Review
通讯作者	Yin, Huiyong
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/2862
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_尹慧勇组生命科学与技术学院_硕士生
通讯作者	Yin, Huiyong
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Food Safety Res, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Chinese Acad Sci, Univ Chinese Acad Sci, Beijing, Peoples R China 4.Minist Hlth, Key Lab Food Safety Risk Assessment, Beijing, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Xiao, Mengqing,Zhong, Huiqin,Xia, Lin,et al. Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria[J]. FREE RADICAL BIOLOGY AND MEDICINE,2017,111:316-327.
APA	Xiao, Mengqing,Zhong, Huiqin,Xia, Lin,Tao, Yongzhen,&Yin, Huiyong.(2017).Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria.FREE RADICAL BIOLOGY AND MEDICINE,111,316-327.
MLA	Xiao, Mengqing,et al."Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria".FREE RADICAL BIOLOGY AND MEDICINE 111(2017):316-327.