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Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23 | |
2018-09-24 | |
发表期刊 | NATURE COMMUNICATIONS |
ISSN | 2041-1723 |
卷号 | 9 |
发表状态 | 已发表 |
DOI | 10.1038/s41467-018-06372-1 |
摘要 | Invariant natural killer T cells (iNKT cells) are a specific subset of T cells that recognize glycolipid antigens and upon activation rapidly exert effector functions. This unique function is established during iNKT cell development; the detailed mechanisms of this process, however, remain to be elucidated. Here the authors show that deletion of the mediator subunit Med23 in CD4(+)CD8(+) double positive (DP) thymocytes completely blocks iNKT cell development at stage 2. This dysregulation is accompanied by a bias in the expression of genes related to the regulation of transcription and metabolism, and functional impairment of the cells including the loss of NK cell characteristics, reduced ability to secrete cytokines and attenuated recruitment capacity upon activation. Moreover, Med23-deficient iNKT cells exhibit impaired anti-tumor activity. Our study identifies Med23 as an essential transcriptional regulator that controls iNKT cell differentiation and terminal maturation. |
收录类别 | SCI ; SCIE |
语种 | 英语 |
资助项目 | China Postdoctoral Science Foundation[2015M581672] |
WOS研究方向 | Science & Technology - Other Topics |
WOS类目 | Multidisciplinary Sciences |
WOS记录号 | WOS:000445329000010 |
出版者 | NATURE PUBLISHING GROUP |
WOS关键词 | KILLER T-CELLS ; NATURAL-KILLER ; NKT CELLS ; TRANSCRIPTIONAL CONTROL ; IFN-GAMMA ; LINEAGE ; MED23 ; DIFFERENTIATION ; ACTIVATION ; EXPRESSION |
原始文献类型 | Article |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27788 |
专题 | 生命科学与技术学院_特聘教授组_刘小龙组 |
通讯作者 | Liu, Xiaolong |
作者单位 | 1.Univ Chinese Acad Sci, State Key Lab Cell Biol, CAS Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol,Chinese Acad Sc, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China |
通讯作者单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Xu, Yu,Sun, Yang,Shen, Hao,et al. Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23[J]. NATURE COMMUNICATIONS,2018,9. |
APA | Xu, Yu.,Sun, Yang.,Shen, Hao.,Dai, Yuling.,Liu, Haifeng.,...&Liu, Xiaolong.(2018).Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.NATURE COMMUNICATIONS,9. |
MLA | Xu, Yu,et al."Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23".NATURE COMMUNICATIONS 9(2018). |
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