Gut microbiota mediates the anti-obesity effect of calorie restriction in mice

doi:10.1038/s41598-018-31353-1

	Gut microbiota mediates the anti-obesity effect of calorie restriction in mice
	Wang, Shuo 1; Huang, Meiqin 1; You, Xue2 ; Zhao, Jingyu 1; Chen, Lanlan 1; Wang, Lin 1; Luo, Yangjun 1; Chen, Yan1,2
	2018-08-29
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	8
发表状态	已发表
DOI	10.1038/s41598-018-31353-1
摘要	Calorie restriction (CR) extends lifespan and elicits numerous effects beneficial to health and metabolism in various model organisms, but the underlying mechanisms are not completely understood. Gut microbiota has been reported to be associated with the beneficial effects of CR; however, it is unknown whether these effects of CR are causally mediated by gut microbiota. In this study, we employed an antibiotic-induced microbiota-depleted mouse model to investigate the functional role of gut microbiota in CR. Depletion of gut microbiota rendered mice resistant to CR-induced loss of body weight, accompanied by the increase in fat mass, the reduction in lean mass and the decline in metabolic rate. Depletion of gut microbiota led to increases in fasting blood glucose and cholesterol levels independent of CR. A few metabolism-modulating hormones including leptin and insulin were altered by CR and/or gut microbiota depletion. In addition, CR altered the composition of gut microbiota with significant increases in major probiotic genera such as Lactobacillus and Bifidobacterium, together with the decrease of Helicobacter. In addition, we performed fecal microbiota transplantation in mice fed with high-fat diet. Mice with transferred microbiota from calorie-restricted mice resisted high fat diet-induced obesity and exhibited metabolic improvement such as alleviated hepatic lipid accumulation. Collectively, these data indicate that CR-induced metabolic improvement especially in body weight reduction is mediated by intestinal microbiota to a certain extent.
收录类别	SCI ; SCIE
语种	英语
资助项目	Chinese Academy of Sciences[XDA12010102] ; Chinese Academy of Sciences[QYZDJ-SSW-SMC008] ; Chinese Academy of Sciences[ZDRW-ZS-2016-8]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000443003800044
出版者	NATURE PUBLISHING GROUP
WOS关键词	ADAPTIVE THERMOGENESIS ; BODY-WEIGHT ; LIFE-SPAN ; RHESUS-MONKEYS ; METABOLIC SYNDROME ; ENERGY-BALANCE ; FOOD-INTAKE ; HUMANS ; DIET ; OBESITY
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27704
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_陈雁组生命科学与技术学院_博士生
通讯作者	Chen, Yan
作者单位	1.Univ Chinese Acad Sci, Shanghai Inst Biol Sci, Chinese Acad Sci, CAS Key Lab Nutr Metab & Food Safety,Shanghai In, Shanghai 200031, Peoples R China 2.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Wang, Shuo,Huang, Meiqin,You, Xue,et al. Gut microbiota mediates the anti-obesity effect of calorie restriction in mice[J]. SCIENTIFIC REPORTS,2018,8.
APA	Wang, Shuo.,Huang, Meiqin.,You, Xue.,Zhao, Jingyu.,Chen, Lanlan.,...&Chen, Yan.(2018).Gut microbiota mediates the anti-obesity effect of calorie restriction in mice.SCIENTIFIC REPORTS,8.
MLA	Wang, Shuo,et al."Gut microbiota mediates the anti-obesity effect of calorie restriction in mice".SCIENTIFIC REPORTS 8(2018).