ShanghaiTech University Knowledge Management System
Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation | |
2018-05-18 | |
发表期刊 | ORGANIC LETTERS (IF:4.9[JCR-2023],4.5[5-Year]) |
ISSN | 1523-7060 |
卷号 | 20期号:10页码:3065-3069 |
发表状态 | 已发表 |
DOI | 10.1021/acs.orglett.8b01099 |
摘要 | An Rh(III)-catalyzed C-H activation of pyrazolones with 1,6-enynes was investigated. The regioselectivity of the C-H activation/alkyne insertion is readily solved by using symmetric enyne coupling partners, and a C-H activation-triggered cascade reaction is realized, which involves alkyne insertion, tautomerization, and double cyclization to offer a class of structurally complex polycyclic architectures. This cascade reaction tolerates a broad substrate scope in high regioselectivity and stereospecificity and furnishes three new chemical bonds and four chiral centers in a single operation. Various derivatizations of the polycyclic scaffolds are conducted, providing products with ample space for further functional transformations. |
收录类别 | SCI ; SCIE ; IC |
语种 | 英语 |
资助项目 | Shanghai Commission of Science and Technology[16XD1404600] |
WOS研究方向 | Chemistry |
WOS类目 | Chemistry, Organic |
WOS记录号 | WOS:000432900200062 |
出版者 | AMER CHEMICAL SOC |
WOS关键词 | DOMINO REACTIONS ; ALKYNYL-CYCLOHEXADIENONES ; ARYLATIVE CYCLIZATION ; PROPARGYLIC ESTERS ; ORGANIC-SYNTHESIS ; DIRECTING GROUPS ; ARENES ; REARRANGEMENT ; STRATEGY ; ALLENES |
原始文献类型 | Article |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27436 |
专题 | 生命科学与技术学院 生命科学与技术学院_特聘教授组_张翱组 生命科学与技术学院_博士生 |
通讯作者 | Zhang, Ao |
作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Coll Pharm, Beijing 100049, Peoples R China |
第一作者单位 | 生命科学与技术学院 |
通讯作者单位 | 生命科学与技术学院 |
第一作者的第一单位 | 生命科学与技术学院 |
推荐引用方式 GB/T 7714 | Lu, Heng,Fan, Zhoulong,Xiong, Chaodong,et al. Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation[J]. ORGANIC LETTERS,2018,20(10):3065-3069. |
APA | Lu, Heng,Fan, Zhoulong,Xiong, Chaodong,&Zhang, Ao.(2018).Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation.ORGANIC LETTERS,20(10),3065-3069. |
MLA | Lu, Heng,et al."Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation".ORGANIC LETTERS 20.10(2018):3065-3069. |
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