Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation
2018-05-18
发表期刊ORGANIC LETTERS (IF:4.9[JCR-2023],4.5[5-Year])
ISSN1523-7060
卷号20期号:10页码:3065-3069
发表状态已发表
DOI10.1021/acs.orglett.8b01099
摘要An Rh(III)-catalyzed C-H activation of pyrazolones with 1,6-enynes was investigated. The regioselectivity of the C-H activation/alkyne insertion is readily solved by using symmetric enyne coupling partners, and a C-H activation-triggered cascade reaction is realized, which involves alkyne insertion, tautomerization, and double cyclization to offer a class of structurally complex polycyclic architectures. This cascade reaction tolerates a broad substrate scope in high regioselectivity and stereospecificity and furnishes three new chemical bonds and four chiral centers in a single operation. Various derivatizations of the polycyclic scaffolds are conducted, providing products with ample space for further functional transformations.
收录类别SCI ; SCIE ; IC
语种英语
资助项目Shanghai Commission of Science and Technology[16XD1404600]
WOS研究方向Chemistry
WOS类目Chemistry, Organic
WOS记录号WOS:000432900200062
出版者AMER CHEMICAL SOC
WOS关键词DOMINO REACTIONS ; ALKYNYL-CYCLOHEXADIENONES ; ARYLATIVE CYCLIZATION ; PROPARGYLIC ESTERS ; ORGANIC-SYNTHESIS ; DIRECTING GROUPS ; ARENES ; REARRANGEMENT ; STRATEGY ; ALLENES
原始文献类型Article
引用统计
正在获取...
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/27436
专题生命科学与技术学院
生命科学与技术学院_特聘教授组_张翱组
生命科学与技术学院_博士生
通讯作者Zhang, Ao
作者单位
1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Coll Pharm, Beijing 100049, Peoples R China
第一作者单位生命科学与技术学院
通讯作者单位生命科学与技术学院
第一作者的第一单位生命科学与技术学院
推荐引用方式
GB/T 7714
Lu, Heng,Fan, Zhoulong,Xiong, Chaodong,et al. Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation[J]. ORGANIC LETTERS,2018,20(10):3065-3069.
APA Lu, Heng,Fan, Zhoulong,Xiong, Chaodong,&Zhang, Ao.(2018).Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation.ORGANIC LETTERS,20(10),3065-3069.
MLA Lu, Heng,et al."Highly Stereoselective Assembly of Polycyclic Molecules from 1,6-Enynes Triggered by Rhodium(III)-Catalyzed C-H Activation".ORGANIC LETTERS 20.10(2018):3065-3069.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Lu, Heng]的文章
[Fan, Zhoulong]的文章
[Xiong, Chaodong]的文章
百度学术
百度学术中相似的文章
[Lu, Heng]的文章
[Fan, Zhoulong]的文章
[Xiong, Chaodong]的文章
必应学术
必应学术中相似的文章
[Lu, Heng]的文章
[Fan, Zhoulong]的文章
[Xiong, Chaodong]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 27436.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。