Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation

doi:10.3389/fnut.2022.1043783

	Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation
	Song, Shuo1,2 ; Chen, Lingling 1; Bai, Meijuan 1; Wang, Shuo 1; Ye, Xiaoyi 1; Lin, Yijun 1; Luo, Xuemei 1; Li, Zixuan 1; Zhang, Lingling 1; Zhu, Xinyu2 ; Wang, Zinan 1; Chen, Yan1,2
	2022-12-23
发表期刊	FRONTIERS IN NUTRITION (IF:4.0[JCR-2023],4.4[5-Year])
ISSN	2296-861X
卷号	9
发表状态	已发表
DOI	10.3389/fnut.2022.1043783
摘要	Time-restricted feeding (TRF) is an emerging dietary intervention that improves metabolic disorders such as obesity, insulin resistance and dyslipidemia. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder affecting the gastrointestinal tract, where nutrition plays an important role in its pathogenesis. Although numerous strategies of nutritional intervention have been reported, whether TRF can improve IBD has been elusive. In this study, we investigated the effect of two cycles of 7-day TRF intervention in a dextran sulfate sodium-induced IBD mouse model. We found that TRF was able to reduce the disease activity index and ameliorate the IBD-associated symptoms, as well as increase the number of colonic crypts and decrease the histological score in the colon. Furthermore, TRF lowered the percentage of CD4(+) T cells in the peripheral blood and mesenteric lymph node, and increased the number of CD4(+)CD25(+) T cells in the mesenteric lymph nodes. Additionally, TRF reduced the infiltration of leukocytes and macrophages around the crypt base in the colon. However, unlike the intermittent caloric restriction with fasting-mimicking diet, TRF was not able to increase the markers of progenitor and cell proliferation in the colon. Collectively, these results demonstrated that TRF is able to improve IBD in mice via reduction in intestinal inflammation.
关键词	inflammatory bowel disease time-restricted feeding intestine inflammation T cells
URL	查看原文
收录类别	SCI
语种	英语
资助项目	[32230047]
WOS研究方向	Nutrition & Dietetics
WOS类目	Nutrition & Dietetics
WOS记录号	WOS:000907891000001
出版者	FRONTIERS MEDIA SA
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/272808
专题	生命科学与技术学院_博士生生命科学与技术学院_特聘教授组_陈雁组
通讯作者	Chen, Yan
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Key Lab Nutr Metab & Food Safety, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Song, Shuo,Chen, Lingling,Bai, Meijuan,et al. Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation[J]. FRONTIERS IN NUTRITION,2022,9.
APA	Song, Shuo.,Chen, Lingling.,Bai, Meijuan.,Wang, Shuo.,Ye, Xiaoyi.,...&Chen, Yan.(2022).Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation.FRONTIERS IN NUTRITION,9.
MLA	Song, Shuo,et al."Time-restricted feeding ameliorates dextran sulfate sodium-induced colitis via reducing intestinal inflammation".FRONTIERS IN NUTRITION 9(2022).