ShanghaiTech University Knowledge Management System
| Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective | |
| 2022-12-01 | |
| Source Publication | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| EISSN | 1422-0067 |
| Volume | 23Issue:23 |
| Status | 已发表 |
| DOI | 10.3390/ijms232314753 |
| Abstract | Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and rigidity, as well as non-motor symptoms such as anosmia, depression, and cognitive impairment. Pathologically, the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN) and the accumulation of alpha-synuclein (alpha-syn)-composed Lewy bodies (LBs) and Lewy neurites (LNs) are key hallmarks. Glia are more than mere bystanders that simply support neurons, they actively contribute to almost every aspect of neuronal development and function; glial dysregulation has been implicated in a series of neurodegenerative diseases including PD. Importantly, amounting evidence has added glial activation and neuroinflammation as new features of PD onset and progression. Thus, gaining a better understanding of glia, especially neuron-glia crosstalk, will not only provide insight into brain physiology events but also advance our knowledge of PD pathologies. This review addresses the current understanding of alpha-syn pathogenesis in PD, with a focus on neuron-glia crosstalk. Particularly, the transmission of alpha-syn between neurons and glia, alpha-syn-induced glial activation, and feedbacks of glial activation on DA neuron degeneration are thoroughly discussed. In addition, alpha-syn aggregation, iron deposition, and glial activation in regulating DA neuron ferroptosis in PD are covered. Lastly, we summarize the preclinical and clinical therapies, especially targeting glia, in PD treatments. |
| Keyword | Parkinson's disease alpha-synuclein glia neuron-glia crosstalk neuroinflammation |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | [31871039] ; [32170962] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| WOS ID | WOS:000898025600001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/272803 |
| Collection | 生命科学与技术学院_博士生 生命科学与技术学院_PI研究组_何淑君组 |
| Corresponding Author | Ho, Margaret S.; Zhang, Shiping |
| Affiliation | ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| First Author Affilication | School of Life Science and Technology |
| Corresponding Author Affilication | School of Life Science and Technology |
| First Signature Affilication | School of Life Science and Technology |
| Recommended Citation GB/T 7714 | Yi, Shuanglong,Wang, Linfang,Wang, Honglei,et al. Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(23). |
| APA | Yi, Shuanglong,Wang, Linfang,Wang, Honglei,Ho, Margaret S.,&Zhang, Shiping.(2022).Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(23). |
| MLA | Yi, Shuanglong,et al."Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.23(2022). |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
Edit Comment
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.