Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective
2022-12-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
EISSN1422-0067
Volume23Issue:23
Status已发表
DOI10.3390/ijms232314753
AbstractParkinson's disease (PD) is a progressive neurodegenerative disorder. The classical behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and rigidity, as well as non-motor symptoms such as anosmia, depression, and cognitive impairment. Pathologically, the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN) and the accumulation of alpha-synuclein (alpha-syn)-composed Lewy bodies (LBs) and Lewy neurites (LNs) are key hallmarks. Glia are more than mere bystanders that simply support neurons, they actively contribute to almost every aspect of neuronal development and function; glial dysregulation has been implicated in a series of neurodegenerative diseases including PD. Importantly, amounting evidence has added glial activation and neuroinflammation as new features of PD onset and progression. Thus, gaining a better understanding of glia, especially neuron-glia crosstalk, will not only provide insight into brain physiology events but also advance our knowledge of PD pathologies. This review addresses the current understanding of alpha-syn pathogenesis in PD, with a focus on neuron-glia crosstalk. Particularly, the transmission of alpha-syn between neurons and glia, alpha-syn-induced glial activation, and feedbacks of glial activation on DA neuron degeneration are thoroughly discussed. In addition, alpha-syn aggregation, iron deposition, and glial activation in regulating DA neuron ferroptosis in PD are covered. Lastly, we summarize the preclinical and clinical therapies, especially targeting glia, in PD treatments.
KeywordParkinson's disease alpha-synuclein glia neuron-glia crosstalk neuroinflammation
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Indexed BySCI
Language英语
Funding Project[31871039] ; [32170962]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000898025600001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttps://kms.shanghaitech.edu.cn/handle/2MSLDSTB/272803
Collection生命科学与技术学院_博士生
生命科学与技术学院_PI研究组_何淑君组
Corresponding AuthorHo, Margaret S.; Zhang, Shiping
Affiliation
ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
First Author AffilicationSchool of Life Science and Technology
Corresponding Author AffilicationSchool of Life Science and Technology
First Signature AffilicationSchool of Life Science and Technology
Recommended Citation
GB/T 7714
Yi, Shuanglong,Wang, Linfang,Wang, Honglei,et al. Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(23).
APA Yi, Shuanglong,Wang, Linfang,Wang, Honglei,Ho, Margaret S.,&Zhang, Shiping.(2022).Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(23).
MLA Yi, Shuanglong,et al."Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.23(2022).
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