Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective

doi:10.3390/ijms232314753

	Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective
	Yi, Shuanglong; Wang, Linfang; Wang, Honglei; Ho, Margaret S.; Zhang, Shiping
	2022-12-01
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
EISSN	1422-0067
卷号	23 期号:23
发表状态	已发表
DOI	10.3390/ijms232314753
摘要	Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and rigidity, as well as non-motor symptoms such as anosmia, depression, and cognitive impairment. Pathologically, the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN) and the accumulation of alpha-synuclein (alpha-syn)-composed Lewy bodies (LBs) and Lewy neurites (LNs) are key hallmarks. Glia are more than mere bystanders that simply support neurons, they actively contribute to almost every aspect of neuronal development and function; glial dysregulation has been implicated in a series of neurodegenerative diseases including PD. Importantly, amounting evidence has added glial activation and neuroinflammation as new features of PD onset and progression. Thus, gaining a better understanding of glia, especially neuron-glia crosstalk, will not only provide insight into brain physiology events but also advance our knowledge of PD pathologies. This review addresses the current understanding of alpha-syn pathogenesis in PD, with a focus on neuron-glia crosstalk. Particularly, the transmission of alpha-syn between neurons and glia, alpha-syn-induced glial activation, and feedbacks of glial activation on DA neuron degeneration are thoroughly discussed. In addition, alpha-syn aggregation, iron deposition, and glial activation in regulating DA neuron ferroptosis in PD are covered. Lastly, we summarize the preclinical and clinical therapies, especially targeting glia, in PD treatments.
关键词	Parkinson's disease alpha-synuclein glia neuron-glia crosstalk neuroinflammation
URL	查看原文
收录类别	SCI
语种	英语
资助项目	[31871039] ; [32170962]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号	WOS:000898025600001
出版者	MDPI
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/272803
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_何淑君组
通讯作者	Ho, Margaret S.; Zhang, Shiping
作者单位	ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
第一作者的第一单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yi, Shuanglong,Wang, Linfang,Wang, Honglei,et al. Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(23).
APA	Yi, Shuanglong,Wang, Linfang,Wang, Honglei,Ho, Margaret S.,&Zhang, Shiping.(2022).Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(23).
MLA	Yi, Shuanglong,et al."Pathogenesis of alpha-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.23(2022).