上海科技大学知识管理系统

The present technology relates generally to compositions and methods of preventing or treating diseases associated with mutantleptin receptors, leptin deficiency or leptin dysfunction. The present technology also relates to administering the anti-leptin receptor antibodies in effective amounts to treat a subject suffering from, or predisposed to, a disease associated with mutant leptin receptors, obesity, leptin deficiency, leptin resistance, and//or hypoleptinemia.

本技术一般涉及预防或治疗与突变瘦素受体，瘦素缺乏或瘦素功能障碍相关的疾病的组合物和方法。 本技术还涉及施用有效量的抗瘦素受体抗体以治疗患有或易患与突变瘦素受体相关的疾病，肥胖，瘦素缺乏，瘦素抗性和//或低肽血症的受试者。