REGENERATION OF RETINAL GANGLION CELLS

	REGENERATION OF RETINAL GANGLION CELLS
翻译题名	视网膜神经节细胞的再生
申请号	US17812381
	2022-11-03
公开（公告）号	US20220347320A1
公开日期	2022-11-03
摘要	Provided herein are compositions and methods for regenerating retinal ganglion cells (RGCs) from retinal neuron cells by activating transcription factors such as one or more of Atoh7, Brn3B, Sox4, Sox11, or Ils1. The retinal neuron cells may be interneuron cells such as amacrine cells, horizontal cells, and bipolar cell. The regenerated RGCs can project axons into discrete subcortical brain regions and establish retina-brain connections. They can respond to visual stimulation and transmit electrical signals into the brain. Therefore, the regenerated RGCs can replace damaged or degenerated RGCs, thereby treating vision impairment or blindness. The methods are likewise applicable to degenerated, damaged, or aged RGCs to stimulate them to regrow functional axons, thereby rejuvenating these RGCs.
翻译摘要	本文提供了通过激活转录因子如ATOH7，BRN3B，SOX4，SOX11或ILS1中的一种或多种从视网膜神经元细胞再生视网膜神经节细胞(RGC)的组合物和方法。视网膜神经元细胞可以是神经元间细胞，例如无突细胞，水平细胞和双极细胞。再生的RGCs可以将轴突投射到离散的皮质下脑区域并建立视网膜-脑连接。它们可以对视觉刺激作出反应并将电信号传送到脑中。因此，再生的RGCs可以替代受损或退化的RGCs，从而治疗视力损伤或失明。该方法同样适用于退化的，受损的或老化的RGCs，以刺激它们再生功能轴突，从而使这些RGCs再生。
当前权利人	Shanghaitech University
专利申请人	Shanghaitech University
	Liu Hongjun; Wei Xiaohu; Qiao Na
公开国别	美国
公开国别简称	US
IPC 分类号	A61K48//00; A61K38//17; A61P27//02; C12N15//86
CPC分类号	A61K38//1709; A61K35//30; A61P27//02; A61P27//06; C12N5//0621; C12N15//86; C12N2506//08; C12N2501//60; C12N2510//00; C12N2750//14143; A01K67//0278; A01K2217//072; A01K2227//105; A01K2267//0393; A01K67//0275; A61K48//005; A61K48//0075; C12N5//062; C12N2501//602; C12N2750//14023; C12N2750//14133; C12N2750//14142
专利有效性	审中
专利类型	发明申请
专利类型字典	1
当前法律状态	实质审查
简单同族	CN113134076A; AU2021208775A1; WO2021143827A1; EP4090751A1; IL294358A; KR1020220130150A; US20220347320A1; CA3165427A1
扩展同族	AU2021208775A1; CN113134076A; KR1020220130150A; CA3165427A1; US20220347320A1; WO2021143827A1; IL294358A; EP4090751A1
INPADOC 同族	EP4090751A1; US20220347320A1; IL294358A; CA3165427A1; KR1020220130150A; WO2021143827A1; AU2021208775A1; CN113134076A
文献类型	专利
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/258908
专题	生命科学与技术学院_PI研究组_刘洪军组生命科学与技术学院_行政办公室生命科学与技术学院_博士生
作者单位	Shanghaitech University
推荐引用方式 GB/T 7714	Liu Hongjun,Wei Xiaohu,Qiao Na. REGENERATION OF RETINAL GANGLION CELLS. US17812381[P]. 2022-11-03.