ShanghaiTech University Knowledge Management System
| Cytoophidia safeguard binucleation of Drosophila male accessory gland cells | |
| 2023 | |
| 发表期刊 | EXPERIMENTAL CELL RESEARCH (IF:3.3[JCR-2023],3.3[5-Year]) |
| ISSN | 0014-4827 |
| EISSN | 1090-2422 |
| 卷号 | 422期号:1 |
| 发表状态 | 已发表 |
| DOI | 10.1016/j.yexcr.2022.113433 |
| 摘要 | Although most cells are mononuclear, the nucleus can exist in the form of binucleate or even multinucleate to respond to different physiological processes. The male accessory gland of Drosophila is the organ that produces semen, and its main cells are binucleate. Here we observe that CTP synthase (CTPS) forms filamentous cytoophidia in binuclear main cells, primarily located at the cell boundary. In CTPS, a point mutation that destroys the formation of cytoophidia, we find that the nucleation mode of the main cells changes, including mononucleates and vertical distribution of binucleates. Although the overexpression of CTPS can restore the level of CTPS protein, it will neither form cytoophidia nor eliminate the abnormal nucleation pattern. Therefore, our data indicate that there is an unexpected functional link between the formation of cytoophidia and the maintenance of binucleation in Drosophila main cells. |
| 关键词 | Accessory gland Binucleation CTP synthase Cytoophidium Drosophila Main cell |
| URL | 查看原文 |
| 收录类别 | SCI ; SCOPUS |
| 语种 | 英语 |
| 资助项目 | [2021YFA0804700] ; [31771490] ; [20JC1410500] ; [MC_UU_12,021/3] ; [MC_U137788471] |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| WOS记录号 | WOS:000904896700003 |
| 出版者 | ELSEVIER INC |
| Scopus 记录号 | 2-s2.0-85143119797 |
| 来源库 | Scopus |
| 引用统计 | 正在获取...
|
| 文献类型 | 期刊论文 |
| 条目标识符 | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/256386 |
| 专题 | 生命科学与技术学院_硕士生 生命科学与技术学院_PI研究组_刘冀珑组 生命科学与技术学院_博士生 |
| 通讯作者 | Liu, Ji-Long |
| 作者单位 | 1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 2.Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 3PT, England |
| 第一作者单位 | 生命科学与技术学院 |
| 通讯作者单位 | 生命科学与技术学院 |
| 第一作者的第一单位 | 生命科学与技术学院 |
| 推荐引用方式 GB/T 7714 | You, Dong-Dong,Zhou, Xiao-Li,Wang, Qiao-Qi,et al. Cytoophidia safeguard binucleation of Drosophila male accessory gland cells[J]. EXPERIMENTAL CELL RESEARCH,2023,422(1). |
| APA | You, Dong-Dong,Zhou, Xiao-Li,Wang, Qiao-Qi,&Liu, Ji-Long.(2023).Cytoophidia safeguard binucleation of Drosophila male accessory gland cells.EXPERIMENTAL CELL RESEARCH,422(1). |
| MLA | You, Dong-Dong,et al."Cytoophidia safeguard binucleation of Drosophila male accessory gland cells".EXPERIMENTAL CELL RESEARCH 422.1(2023). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
修改评论
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。