Stability and dynamics of dendritic spines in macaque prefrontal cortex

doi:10.1093/nsr/nwac125

	Stability and dynamics of dendritic spines in macaque prefrontal cortex
	Chen, Ming 1; Qi, Junqian1,2,3 ; Poo, Muming1,2,3,4 ; Yang, Yang2
	2022-09-29
发表期刊	NATIONAL SCIENCE REVIEW (IF:16.3[JCR-2023],18.6[5-Year])
ISSN	2095-5138
EISSN	2053-714X
卷号	9 期号:9
发表状态	已发表
DOI	10.1093/nsr/nwac125
摘要	["Reported high resolution long-term observation of dendritic spines in macaque, demonstrated the spine dynamics of L5 dlPFC neurons in puberty and adult monkeys and the spatial rule of spine distribution.","Formation and elimination of synapses reflect structural plasticity of neuronal connectivity. Here we performed high-resolution two-photon imaging of dendritic spines in the prefrontal cortex of four macaque monkeys and found that spines were in general highly stable, with low percentages undergoing synaptic turnover. By observing the same spines at weekly intervals, we found that newly formed spines were more susceptible to elimination, with only 40% persisting over a period of months. Analyses of spatial distribution of large numbers of spines revealed that spine distribution was neither uniform nor random, favoring inter-spine distances of 2-4 mu m. Furthermore, spine formation and elimination occurred more often in low- and high-density dendritic segments, respectively, and preferentially within a hot zone of similar to 4 mu m from existing spines. Our results demonstrate long-term stability and spatially regulated spine dynamics in the macaque cortex and provide a structural basis for understanding neural circuit plasticity in the primate brain."]
关键词	long-term two-photon imaging macaque monkey spine plasticity dendritic spine distribution regulation of spine dynamics dorsal lateral prefrontal cortex
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收录类别	SCI ; SCIE ; EI
语种	英语
资助项目	Shanghai Municipal Science and Technology Major Project["2018SHZDZX05","2021SHZDZX"] ; Shanghai Municipal Science and Technology Project[21015800100] ; Strategic Priority Research Program of CAS[XDB32070100] ; Key Research Program of Frontier Sciences of CAS["QYZDY-SSW-SMCO01","153D31KYSB20170059","2021050107"] ; National Natural Science Foundation of China[31970960]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000861518100001
出版者	OXFORD UNIV PRESS
引用统计	正在获取...
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/238166
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_杨扬组生命科学与技术学院_特聘教授组_蒲慕明组
通讯作者	Poo, Muming; Yang, Yang
作者单位	1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Key Lab Primate Neurobiol, Inst Neurosci,State Key Lab Neurosci, Shanghai 200031, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Lingang Lab, Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai 200031, Peoples R China
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Chen, Ming,Qi, Junqian,Poo, Muming,et al. Stability and dynamics of dendritic spines in macaque prefrontal cortex[J]. NATIONAL SCIENCE REVIEW,2022,9(9).
APA	Chen, Ming,Qi, Junqian,Poo, Muming,&Yang, Yang.(2022).Stability and dynamics of dendritic spines in macaque prefrontal cortex.NATIONAL SCIENCE REVIEW,9(9).
MLA	Chen, Ming,et al."Stability and dynamics of dendritic spines in macaque prefrontal cortex".NATIONAL SCIENCE REVIEW 9.9(2022).