PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest

doi:10.1038/s41467-022-32976-9

	PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest
	Yuan, Yangyang1,2,7 ; Wang, Chenwei 3; Zhuang, Xuran2 ; Lin, Shaofeng 3; Luo, Miaomiao 1; Deng, Wankun 3; Zhou, Jiaqi 3; Liu, Lihui 1; Mao, Lina 1; Peng, Wenbo2 ; Chen, Jian 4,5; Wang, Qiangsong 1; Shu, Yilai 4,5; Xue, Yu 3,6; Huang, Pengyu1,2
	2022-09-06
发表期刊	NATURE COMMUNICATIONS
EISSN	2041-1723
卷号	13 期号:1
发表状态	已发表
DOI	10.1038/s41467-022-32976-9
摘要	Protein kinase-mediated phosphorylation plays a critical role in many biological processes. However, the identification of key regulatory kinases is still a great challenge. Here, we develop a trans-omics-based method, central kinase inference, to predict potentially key kinases by integrating quantitative transcriptomic and phosphoproteomic data. Using known kinases associated with anti-cancer drug resistance, the accuracy of our method denoted by the area under the curve is 5.2% to 29.5% higher than Kinase-Substrate Enrichment Analysis. We further use this method to analyze trans-omic data in hepatocyte maturation and hepatic reprogramming of human dermal fibroblasts, uncovering 5 kinases as regulators in the two processes. Further experiments reveal that a serine/threonine kinase, PIM1, promotes hepatic conversion and protects human dermal fibroblasts from reprogramming-induced ferroptosis and cell cycle arrest. This study not only reveals new regulatory kinases, but also provides a helpful method that might be extended to predict central kinases involved in other biological processes.
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收录类别	SCI ; SCIE
语种	英语
资助项目	Ministry of Science and Technology of China (MOST)["2019YFA0801501","2016YFA0100500"] ; CAMS Innovation Fund for Medical Sciences["2021I2M-1-058","2022-I2M-2-003"] ; Tianjin Natural Science Foundation for Distinguished Young Scholars[21JCJQJC00030] ; NSFC["31970687","82171148","81822011"] ; National Key R&D Program of China["2021YFF0702000","2021ZD0201300","2020YFA0908201"] ; Hubei Natural Science Foundation for Innovative Research Groups[2021CFA005] ; Shanghai Sailing Plan for the Young Scientific Talents[19YF1434000] ; Chinese Postdoctoral Science Foundation[2020M682395]
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000851930300024
出版者	NATURE PORTFOLIO
Scopus 记录号	2-s2.0-85137311481
来源库	Scopus
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/231983
专题	生命科学与技术学院_博士生生命科学与技术学院_PI研究组_黄鹏羽组生命科学与技术学院_PI研究组_向阳飞组
通讯作者	Shu, Yilai; Xue, Yu; Huang, Pengyu
作者单位	1.Institute of Biomedical Engineering,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300192,China 2.School of Life Science and Technology,ShanghaiTech University,Shanghai,201210,China 3.MOE Key Laboratory of Molecular Biophysics,Hubei Bioinformatics and Molecular Imaging Key Laboratory,Center for Artificial Intelligence Biology,Institute of Artificial Intelligence,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan,Hubei,430074,China 4.ENT institute and Department of Otorhinolaryngology,Eye & ENT Hospital,State Key Laboratory of Medical Neurobiology and Institutes of Biomedical Sciences,Fudan University,Shanghai,200031,China 5.NHC Key Laboratory of Hearing Medicine,Fudan University,Shanghai,200031,China 6.Nanjing University Institute of Artificial Intelligence Biomedicine,Nanjing,Jiangsu,210031,China 7.Centre for Translational Stem Cell Biology Limited,999077,Hong Kong
第一作者单位	生命科学与技术学院
通讯作者单位	生命科学与技术学院
推荐引用方式 GB/T 7714	Yuan, Yangyang,Wang, Chenwei,Zhuang, Xuran,et al. PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest[J]. NATURE COMMUNICATIONS,2022,13(1).
APA	Yuan, Yangyang.,Wang, Chenwei.,Zhuang, Xuran.,Lin, Shaofeng.,Luo, Miaomiao.,...&Huang, Pengyu.(2022).PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest.NATURE COMMUNICATIONS,13(1).
MLA	Yuan, Yangyang,et al."PIM1 promotes hepatic conversion by suppressing reprogramming-induced ferroptosis and cell cycle arrest".NATURE COMMUNICATIONS 13.1(2022).