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| Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice | |
| 2018-06-05 | |
| Source Publication | FRONTIERS IN AGING NEUROSCIENCE
 |
| ISSN | 1663-4365 |
| Volume | 10 |
| Status | 已发表 |
| DOI | 10.3389/fnagi.2018.00169 |
| Abstract | Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder with abnormal accumulation of amyloid-beta (A beta) plaques, neuroinflammation and impaired neurogenesis. Mounting evidences suggest that single-target drugs have limited effects on clinical treatment and alternative or multiple targets are required. In recent decades, natural compounds and their derivatives have gained increasing attention in AD drug discovery due to their inherently enormous chemical and structural diversity. In this study, we demonstrated that naringin dihydrochalcone (NDC), a widely used dietary sweetener with strong antioxidant activity, improved the cognitive function of transgenic AD mice. Pathologically, NDC attenuated A beta deposition in AD mouse brain. Furthermore, NDC reduced periplaque activated microglia and astrocytes, indicating the inhibition of neuroinflammation. It also enhanced neurogenesis as investigated by BrdU/NeuN double labeling. Additionally, the inhibition of Ab level and neuroinflammation by NDC treatment was also observed in an AD cell model or a microglia cell line. Taken together, our study indicated that NDC might be a potential therapeutic agent for the treatment of AD against multiple targets that include A beta pathology, neuroinflammation and neurogenesis. |
| Keyword | naringin dihydrochalcone Alzheimer's disease amyloid-beta neuroinflammation neurogenesis |
| Indexed By | SCI ; SCIE |
| Language | 英语 |
| Funding Project | Shanghai Municipal Commission for Science and Technology[15JC1400202] |
| WOS Research Area | Geriatrics & Gerontology ; Neurosciences & Neurology |
| WOS Subject | Geriatrics & Gerontology ; Neurosciences |
| WOS ID | WOS:000434155000001 |
| Publisher | FRONTIERS MEDIA SA |
| WOS Keyword | ADULT HIPPOCAMPAL NEUROGENESIS ; A-BETA LEVELS ; ALZHEIMERS-DISEASE ; VITAMIN-E ; AMYLOID DEPOSITION ; MOUSE MODEL ; CURCUMIN ; MEMORY ; TRIAL ; NEUROINFLAMMATION |
| Original Document Type | Article |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/23083 |
| Collection | 生命科学与技术学院 生命科学与技术学院_特聘教授组_裴钢组 生命科学与技术学院_硕士生 |
| Corresponding Author | Huang, Shichao; Pei, Gang |
| Affiliation | 1.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Chinese Acad Sci, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Lab Receptor Based Biomed, Shanghai, Peoples R China 4.Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Wenjuan,Zhou, Keyan,Zhou, Yue,et al. Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10. |
| APA | Yang, Wenjuan.,Zhou, Keyan.,Zhou, Yue.,An, Yuqian.,Hu, Tingting.,...&Pei, Gang.(2018).Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice.FRONTIERS IN AGING NEUROSCIENCE,10. |
| MLA | Yang, Wenjuan,et al."Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice".FRONTIERS IN AGING NEUROSCIENCE 10(2018). |
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