Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice

doi:10.3389/fnagi.2018.00169

	Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
	Yang, Wenjuan 1; Zhou, Keyan1,2 ; Zhou, Yue 1; An, Yuqian 1; Hu, Tingting 1; Lu, Jing 1; Huang, Shichao 3; Pei, Gang1,4
	2018-06-05
发表期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
卷号	10
发表状态	已发表
DOI	10.3389/fnagi.2018.00169
摘要	Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder with abnormal accumulation of amyloid-beta (A beta) plaques, neuroinflammation and impaired neurogenesis. Mounting evidences suggest that single-target drugs have limited effects on clinical treatment and alternative or multiple targets are required. In recent decades, natural compounds and their derivatives have gained increasing attention in AD drug discovery due to their inherently enormous chemical and structural diversity. In this study, we demonstrated that naringin dihydrochalcone (NDC), a widely used dietary sweetener with strong antioxidant activity, improved the cognitive function of transgenic AD mice. Pathologically, NDC attenuated A beta deposition in AD mouse brain. Furthermore, NDC reduced periplaque activated microglia and astrocytes, indicating the inhibition of neuroinflammation. It also enhanced neurogenesis as investigated by BrdU/NeuN double labeling. Additionally, the inhibition of Ab level and neuroinflammation by NDC treatment was also observed in an AD cell model or a microglia cell line. Taken together, our study indicated that NDC might be a potential therapeutic agent for the treatment of AD against multiple targets that include A beta pathology, neuroinflammation and neurogenesis.
关键词	naringin dihydrochalcone Alzheimer's disease amyloid-beta neuroinflammation neurogenesis
收录类别	SCI ; SCIE
语种	英语
资助项目	Shanghai Municipal Commission for Science and Technology[15JC1400202]
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS记录号	WOS:000434155000001
出版者	FRONTIERS MEDIA SA
WOS关键词	ADULT HIPPOCAMPAL NEUROGENESIS ; A-BETA LEVELS ; ALZHEIMERS-DISEASE ; VITAMIN-E ; AMYLOID DEPOSITION ; MOUSE MODEL ; CURCUMIN ; MEMORY ; TRIAL ; NEUROINFLAMMATION
原始文献类型	Article
引用统计
文献类型	期刊论文
条目标识符	https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/23083
专题	生命科学与技术学院生命科学与技术学院_特聘教授组_裴钢组生命科学与技术学院_硕士生
通讯作者	Huang, Shichao; Pei, Gang
作者单位	1.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Chinese Acad Sci, Shanghai, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China 3.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Lab Receptor Based Biomed, Shanghai, Peoples R China 4.Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Yang, Wenjuan,Zhou, Keyan,Zhou, Yue,et al. Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10.
APA	Yang, Wenjuan.,Zhou, Keyan.,Zhou, Yue.,An, Yuqian.,Hu, Tingting.,...&Pei, Gang.(2018).Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice.FRONTIERS IN AGING NEUROSCIENCE,10.
MLA	Yang, Wenjuan,et al."Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice".FRONTIERS IN AGING NEUROSCIENCE 10(2018).