Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice
Yang, Wenjuan1; Zhou, Keyan1,2; Zhou, Yue1; An, Yuqian1; Hu, Tingting1; Lu, Jing1; Huang, Shichao3; Pei, Gang1,4
2018-06-05
发表期刊FRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
卷号10
发表状态已发表
DOI10.3389/fnagi.2018.00169
摘要Alzheimer's disease (AD) is a multi-factorial neurodegenerative disorder with abnormal accumulation of amyloid-beta (A beta) plaques, neuroinflammation and impaired neurogenesis. Mounting evidences suggest that single-target drugs have limited effects on clinical treatment and alternative or multiple targets are required. In recent decades, natural compounds and their derivatives have gained increasing attention in AD drug discovery due to their inherently enormous chemical and structural diversity. In this study, we demonstrated that naringin dihydrochalcone (NDC), a widely used dietary sweetener with strong antioxidant activity, improved the cognitive function of transgenic AD mice. Pathologically, NDC attenuated A beta deposition in AD mouse brain. Furthermore, NDC reduced periplaque activated microglia and astrocytes, indicating the inhibition of neuroinflammation. It also enhanced neurogenesis as investigated by BrdU/NeuN double labeling. Additionally, the inhibition of Ab level and neuroinflammation by NDC treatment was also observed in an AD cell model or a microglia cell line. Taken together, our study indicated that NDC might be a potential therapeutic agent for the treatment of AD against multiple targets that include A beta pathology, neuroinflammation and neurogenesis.
关键词naringin dihydrochalcone Alzheimer's disease amyloid-beta neuroinflammation neurogenesis
收录类别SCI ; SCIE
语种英语
资助项目Shanghai Municipal Commission for Science and Technology[15JC1400202]
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000434155000001
出版者FRONTIERS MEDIA SA
WOS关键词ADULT HIPPOCAMPAL NEUROGENESIS ; A-BETA LEVELS ; ALZHEIMERS-DISEASE ; VITAMIN-E ; AMYLOID DEPOSITION ; MOUSE MODEL ; CURCUMIN ; MEMORY ; TRIAL ; NEUROINFLAMMATION
原始文献类型Article
引用统计
文献类型期刊论文
条目标识符https://kms.shanghaitech.edu.cn/handle/2MSLDSTB/23083
专题生命科学与技术学院
生命科学与技术学院_特聘教授组_裴钢组
生命科学与技术学院_硕士生
通讯作者Huang, Shichao; Pei, Gang
作者单位1.Univ Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci, State Key Lab Cell Biol,Chinese Acad Sci, Shanghai, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
3.Tongji Univ, Shanghai Key Lab Signaling & Dis Res, Sch Life Sci & Technol, Lab Receptor Based Biomed, Shanghai, Peoples R China
4.Tongji Univ, Sch Life Sci & Technol, Collaborat Innovat Ctr Brain Sci, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Yang, Wenjuan,Zhou, Keyan,Zhou, Yue,et al. Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10.
APA Yang, Wenjuan.,Zhou, Keyan.,Zhou, Yue.,An, Yuqian.,Hu, Tingting.,...&Pei, Gang.(2018).Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice.FRONTIERS IN AGING NEUROSCIENCE,10.
MLA Yang, Wenjuan,et al."Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice".FRONTIERS IN AGING NEUROSCIENCE 10(2018).
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